[HTML][HTML] Visceral leishmaniasis: epidemiology, diagnosis, and treatment regimens in different geographical areas with a focus on pediatrics

S Scarpini, A Dondi, C Totaro, C Biagi, F Melchionda… - Microorganisms, 2022 - mdpi.com
Visceral Leishmaniasis (VL) is a vector-borne disease caused by an intracellular protozoa of
the genus Leishmania that can be lethal if not treated. VL is caused by Leishmania donovani …

Current leishmaniasis drug discovery

AC Pinheiro, MVN de Souza - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
Leishmaniasis is a complex protozoan infectious disease and, associated with malnutrition,
poor health services and unavailability of prophylactic control measures, neglected …

Semantic web-based diagnosis and treatment of vector-borne diseases using SWRL rules

R Chandra, S Tiwari, S Agarwal, N Singh - Knowledge-Based Systems, 2023 - Elsevier
Vector-borne diseases (VBDs) are a kind of infection caused through the transmission of
vectors generated by the bites of infected parasites, bacteria, and viruses, such as ticks …

[HTML][HTML] Human leishmaniasis vaccines: Use cases, target population and potential global demand

S Malvolti, M Malhame, CF Mantel… - PLoS Neglected …, 2021 - journals.plos.org
The development of vaccines against one or all forms of human leishmaniasis remains
hampered by a paucity of investment, at least in part resulting from the lack of well …

[HTML][HTML] Host–pathogen interaction in leishmaniasis: immune response and vaccination strategies

H Yasmin, A Adhikary, MN Al-Ahdal, S Roy, U Kishore - Immuno, 2022 - mdpi.com
Leishmaniasis is a zoonotic and vector-borne infectious disease that is caused by the genus
Leishmania belonging to the trypanosomatid family. The protozoan parasite has a digenetic …

Virulence factors of Leishmania parasite: Their paramount importance in unraveling novel vaccine candidates and therapeutic targets

D Kumari, S Mahajan, P Kour, K Singh - Life sciences, 2022 - Elsevier
Leishmaniasis is a neglected tropical disease and remains a global concern for healthcare.
It is caused by an opportunistic protozoan parasite belonging to the genus Leishmania and …

Overcoming roadblocks in the development of vaccines for leishmaniasis

PM Kaye, S Mohan, C Mantel, M Malhame… - Expert Review of …, 2021 - Taylor & Francis
Introduction The leishmaniases represent a group of parasitic diseases caused by infection
with one of several species of Leishmania parasites. Disease presentation varies because …

[HTML][HTML] The History of Live Attenuated Centrin Gene-Deleted Leishmania Vaccine Candidates

G Volpedo, P Bhattacharya, S Gannavaram… - Pathogens, 2022 - mdpi.com
Leishmaniasis, caused by an infection of the Leishmania protozoa, is a neglected tropical
disease and a major health problem in tropical and subtropical regions of the world, with …

[HTML][HTML] Cell entry and innate sensing shape adaptive immune responses to adenovirus-based vaccines

S Marquez-Martinez, A Vijayan, S Khan… - Current Opinion in …, 2023 - Elsevier
Highlights•Adenoviruses display broad tropism due to use of ubiquitous cell surface
receptors.•Modifications to capsid proteins or genomic regions alter innate immune …

[HTML][HTML] Recent advances in the development of adenovirus-vectored vaccines for parasitic infections

C Koger-Pease, DJ Perera, M Ndao - Pharmaceuticals, 2023 - mdpi.com
Vaccines against parasites have lagged centuries behind those against viral and bacterial
infections, despite the devastating morbidity and widespread effects of parasitic diseases …