Protein biopharmaceuticals are macromolecules with a therapeutic effect, commonly
produced by the recombinant DNA technology. They have emerged as important …

Ion-exchange chromatography (IEX) is a historical technique widely used for the detailed
characterization of therapeutic proteins and can be considered as a reference and powerful …

Despite the popularity of therapeutic monoclonal antibodies (mAbs), data relative to their
ionic physico-chemical properties are very scarce in the literature. In this work, isoelectric …

Monoclonal antibodies (mAbs) are a fast-growing class of biopharmaceuticals. They are
widely used in the identification and detection of cell makers, serum analytes, and …

Since its commercial introduction in 2004, there has been a considerable interest in ultra-
high-performance (pressure) liquid chromatography (UHPLC), which dramatically increases …

Capillary electrophoresis (CE) played an important role in developments in the life sciences.
The technique is nowadays used for the analysis of both large and small molecules in …

Protein biopharmaceuticals such as monoclonal antibodies and therapeutic proteins are
currently in widespread use for the treatment of various life-threatening diseases including …

In therapeutic monoclonal antibody (mAb) development, charge heterogeneity of a mAb
molecule is often associated with critical quality attributes and is therefore monitored …

Passive and active targeted nanoparticulate delivery systems show promise to compensate
for lacking properties of conventional therapy such as side effects, insufficient efficiency and …

Ion exchange chromatography (IEX) is a historical technique widely used for the detailed
characterization of therapeutic proteins and can be considered as a reference and powerful …