Positive impulsive control of tumor therapy—a cyber-medical approach

L Kovács, T Ferenci, B Gombos… - … on Systems, Man …, 2023 - ieeexplore.ieee.org
Chemotherapy optimization based on mathematical models is a promising direction of
personalized medicine. Personalizing, thus optimizing treatments, may have multiple …

Experimental data-driven tumor modeling for chemotherapy

DA Drexler, T Ferenci, A Füredi, G Szakács… - IFAC-PapersOnLine, 2020 - Elsevier
Mathematical models of tumor growth in response to chemotherapy are crucial for therapy
optimization and outcome. We create a relatively simple tumor growth model describing the …

Experimental Closed‐Loop Control of Breast Cancer in Mice

L Kovács, B Czakó, M Siket, T Ferenci, A Füredi… - …, 2022 - Wiley Online Library
Cancer therapy optimization is an issue that can be solved using the control engineering
approach. An optimal therapy generation algorithm is presented and tested using a tractable …

In silico chemotherapy optimization with genetic algorithm

MF Dömény, M Puskás, L Kovács… - 2023 IEEE 17th …, 2023 - ieeexplore.ieee.org
The combination of medicine with engineering has great potential. The currently used
chemotherapy treatments usually use maximal tolerable doses, which can lead to harmful …

Indirect supervised fine-tuning of a tumor model parameter estimator neural network

L Kisbenedek, M Puskás, L Kovács… - 2023 IEEE 17th …, 2023 - ieeexplore.ieee.org
Personalized therapy based on mathematical foundations is a promising method for treating
various types of cancer. By identifying the parameters of mathematical equations, we could …

State and parameter estimation of a mathematical carcinoma model under chemotherapeutic treatment

M Siket, G Eigner, DA Drexler, I Rudas, L Kovács - Applied Sciences, 2020 - mdpi.com
One challenging aspect of therapy optimization and application of control algorithms in the
field of tumor growth modeling is the limited number of measurable physiological signals …

Comparison of artificial neural network and anfis for parameter estimation of a tumor model

E Nagy, M Puskás, DA Drexler - 2022 IEEE 20th Jubilee World …, 2022 - ieeexplore.ieee.org
Cyber-medical systems are revolutionizing medicine. Mathematical therapy optimization is
one of the main pioneering results of cyber-medical system approach. Mathematical therapy …

Model predictive fuzzy control in chemotherapy optimization

TD Szűcs, M Puskás, DA Drexler… - 2023 IEEE 17th …, 2023 - ieeexplore.ieee.org
Nowadays clinical therapies in chemotherapy sessions are generalized for patients,
therefore we are working to provide a personalized drug plan to help reduce the drug …

Tumor model parameter estimation for therapy optimization using artificial neural networks

M Puskás, DA Drexler - 2021 IEEE International Conference on …, 2021 - ieeexplore.ieee.org
Therapy optimization and personalization in cancer treatment requires reliable mathematical
models. A key issue in personalization is the identification of the model parameters. We …

Parameter estimation from realistic experiment scenario using artificial neural networks

M Puskás, B Gergics, A Ládi… - 2022 IEEE 16th …, 2022 - ieeexplore.ieee.org
One of the promising directions in future medicine is the optimization of therapies based on
mathematical and engi-neering methods, with which the treatment can be personalized. In …