The expanding vistas of spatial transcriptomics
The formation and maintenance of tissue integrity requires complex, coordinated activities
by thousands of genes and their encoded products. Until recently, transcript levels could …
by thousands of genes and their encoded products. Until recently, transcript levels could …
Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)
Abstract The Human BioMolecular Atlas Program (HuBMAP) aims to create a multi-scale
spatial atlas of the healthy human body at single-cell resolution by applying advanced …
spatial atlas of the healthy human body at single-cell resolution by applying advanced …
Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function
Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression
The proximal tubule is a key regulator of kidney function and glucose metabolism. Diabetic
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …
kidney disease leads to proximal tubule injury and changes in chromatin accessibility that …
Kidney fibrosis: from mechanisms to therapeutic medicines
R Huang, P Fu, L Ma - Signal Transduction and Targeted Therapy, 2023 - nature.com
Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …
Anatomical structures, cell types and biomarkers of the Human Reference Atlas
Abstract The Human Reference Atlas (HRA) aims to map all of the cells of the human body
to advance biomedical research and clinical practice. This Perspective presents …
to advance biomedical research and clinical practice. This Perspective presents …
SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes
JA Schaub, FM AlAkwaa, PJ McCown… - The Journal of …, 2023 - Am Soc Clin Investig
The molecular mechanisms of sodium-glucose cotransporter-2 (SGLT2) inhibitors (SGLT2i)
remain incompletely understood. Single-cell RNA sequencing and morphometric data were …
remain incompletely understood. Single-cell RNA sequencing and morphometric data were …
Human ureteric bud organoids recapitulate branching morphogenesis and differentiate into functional collecting duct cell types
M Shi, KW McCracken, AB Patel, W Zhang… - Nature …, 2023 - nature.com
Directed differentiation of human pluripotent stem cells (hPSCs) into functional ureteric and
collecting duct (CD) epithelia is essential to kidney regenerative medicine. Here we describe …
collecting duct (CD) epithelia is essential to kidney regenerative medicine. Here we describe …
Decoding the tumor microenvironment with spatial technologies
LA Walsh, DF Quail - Nature Immunology, 2023 - nature.com
Visualization of the cellular heterogeneity and spatial architecture of the tumor
microenvironment (TME) is becoming increasingly important to understand mechanisms of …
microenvironment (TME) is becoming increasingly important to understand mechanisms of …
Lineage tracing and single-nucleus multiomics reveal novel features of adaptive and maladaptive repair after acute kidney injury
LMS Gerhardt, K Koppitch, J van Gestel… - Journal of the …, 2023 - journals.lww.com
Background AKI triggers a proliferative response as part of an intrinsic cellular repair
program, which can lead to adaptive renal repair, restoring kidney structure and function, or …
program, which can lead to adaptive renal repair, restoring kidney structure and function, or …