The T cell immune response against SARS-CoV-2

P Moss - Nature immunology, 2022 - nature.com
The adaptive immune response is a major determinant of the clinical outcome after SARS-
CoV-2 infection and underpins vaccine efficacy. T cell responses develop early and …

Risk factors for severe and critically ill COVID‐19 patients: a review

Y Gao, M Ding, X Dong, J Zhang, A Kursat Azkur… - Allergy, 2021 - Wiley Online Library
The pandemic of coronavirus disease 2019 (COVID‐19), caused by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused an unprecedented global …

[HTML][HTML] Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine

M Levine-Tiefenbrun, I Yelin, R Katz, E Herzel… - Nature medicine, 2021 - nature.com
Beyond their substantial protection of individual vaccinees, coronavirus disease 2019
(COVID-19) vaccines might reduce viral load in breakthrough infection and thereby further …

[HTML][HTML] Evolution of antibody immunity to SARS-CoV-2

C Gaebler, Z Wang, JCC Lorenzi, F Muecksch, S Finkin… - Nature, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 78 million
individuals and is responsible for over 1.7 million deaths to date. Infection is associated with …

Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections

P Zimmermann, N Curtis - Archives of disease in childhood, 2021 - adc.bmj.com
In contrast to other respiratory viruses, children have less severe symptoms when infected
with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this …

COVID-19 vaccines: The status and perspectives in delivery points of view

JY Chung, MN Thone, YJ Kwon - Advanced drug delivery reviews, 2021 - Elsevier
Due to the high prevalence and long incubation periods often without symptoms, the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected millions of individuals …

Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

L Bergamaschi, F Mescia, L Turner, AL Hanson… - Immunity, 2021 - cell.com
The kinetics of the immune changes in COVID-19 across severity groups have not been
rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine …

COVID-19 and solid organ transplantation: a review article

Y Azzi, R Bartash, J Scalea, P Loarte-Campos… - …, 2021 - journals.lww.com
The coronavirus pandemic has significantly impacted solid organ transplantation (SOT).
Early in the outbreak period, transplant societies recommended suspending living kidney …

Global absence and targeting of protective immune states in severe COVID-19

AJ Combes, T Courau, NF Kuhn, KH Hu, A Ray… - Nature, 2021 - nature.com
Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
pleiotropic and systemic effects in some individuals,–, many others experience milder …

Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial

JJ Feld, C Kandel, MJ Biondi, RA Kozak… - The Lancet …, 2021 - thelancet.com
Background To date, only monoclonal antibodies have been shown to be effective for
outpatients with COVID-19. Interferon lambda-1 is a type III interferon involved in innate …