Many of the internal organ systems of Drosophila melanogaster are functionally analogous
to those in vertebrates, including humans. Although humans and flies differ greatly in terms …

Although the genetic basis of many kidney diseases is being rapidly elucidated, their
experimental study remains problematic owing to the lack of suitable models. The fruitfly …

Identification of single-gene causes of steroid-resistant nephrotic syndrome (SRNS) has
furthered the understanding of the pathogenesis of this disease. Here, using a combination …

Nephrotic syndrome (NS) is divided into steroid-sensitive (SSNS) and-resistant (SRNS)
variants. SRNS causes end-stage kidney disease, which cannot be cured. While the disease …

Steroid-resistant nephrotic syndrome (SRNS) is a frequent cause of progressive renal
function decline and affects millions of people. In a recent study, 30% of SRNS cases …

Recent advances in single-cell sequencing provide a unique opportunity to gain novel
insights into the diversity, lineage, and functions of cell types constituting a tissue/organ …

Damage to and loss of glomerular podocytes has been identified as the culprit lesion in
progressive kidney diseases. Here, we combine mass spectrometry-based proteomics with …

Age-related impairment of macroautophagy/autophagy and loss of cardiac tissue
homeostasis contribute significantly to cardiovascular diseases later in life. MTOR …

The circulatory system of Drosophila melanogaster represents an easily amenable genetic
model whose analysis at different levels, ie, from single molecules up to functional anatomy …

APOL1 harbors C–terminal sequence variants (G1 and G2), which account for much of the
increased risk for kidney disease in sub–Saharan African ancestry populations. Expression …