Icariin, an up-and-coming bioactive compound against neurological diseases: network pharmacology-based study and literature review

S Wang, J Ma, Y Zeng, G Zhou, Y Wang… - Drug design …, 2021 - Taylor & Francis
Icariin is a biologically active substance in Epimedii herba that is used for the treatment of
neurologic disorders. However, a comprehensive analysis of the molecular mechanisms of …

[HTML][HTML] The burden of Parkinson's disease in the Middle East and North Africa region, 1990–2019: results from the global burden of disease study 2019

S Safiri, M Noori, SA Nejadghaderi, SE Mousavi… - BMC public health, 2023 - Springer
Background Parkinson's disease (PD) remains a common disabling progressive
neurodegenerative disorder. We aimed to report the prevalence, death and disability …

[HTML][HTML] iPSC-sEVs alleviate microglia senescence to protect against ischemic stroke in aged mice

X Niu, Y Xia, L Luo, Y Chen, J Yuan, J Zhang… - Materials Today Bio, 2023 - Elsevier
The polarization of microglia plays an important role in the outcome of ischemic stroke (IS).
In the aged population, senescent microglia show a predominant pro-inflammatory …

[HTML][HTML] Application and advances of biomimetic membrane materials in central nervous system disorders

W Liao, Z Lu, C Wang, X Zhu, Y Yang, Y Zhou… - Journal of …, 2024 - Springer
Central nervous system (CNS) diseases encompass spinal cord injuries, brain tumors,
neurodegenerative diseases, and ischemic strokes. Recently, there has been a growing …

[HTML][HTML] Cerebrospinal fluid-derived extracellular vesicles after spinal cord injury promote vascular regeneration via PI3K/AKT signaling pathway

C Li, T Qin, Y Jin, J Hu, F Yuan, Y Cao… - Journal of Orthopaedic …, 2023 - Elsevier
Background The cerebrospinal fluid (CSF), which surrounds the brain and spinal cord, is
predominantly produced by the choroid plexus of the ventricle. Although CSF-derived …

Development of portable robotic orthosis and biomechanical validation in people with limited upper limb function after stroke

FMRM Ferreira, G de Paula Rúbio, RMA Dutra… - Robotica, 2022 - cambridge.org
Stroke has a considerable incidence in the world population and would cause sequelae in
the upper limbs. One way to increase the efficiency in the rehabilitation process of patients …

Ligand profiling as a diagnostic tool to differentiate patient-derived α-synuclein polymorphs

TS Chisholm, R Melki, CA Hunter - ACS Chemical Neuroscience, 2024 - ACS Publications
Amyloid fibrils are characteristic of many neurodegenerative diseases, including Alzheimer's
and Parkinson's diseases. While different diseases may have fibrils formed of the same …

[PDF][PDF] Implications of United States Service Evidence for Growing Multiethnic Adult Neurorehabilitation Caseloads Worldwide.

JG Centeno, JL Harris - … Journal of Speech-Language Pathology & …, 2021 - researchgate.net
The interaction of worldwide population aging with the concurrent growth in global
ethnoracial diversity is estimated to substantially expand ethnogeriatric neurorehabilitation …

[HTML][HTML] Identifying therapeutic target genes for migraine by systematic druggable genome-wide Mendelian randomization

C Zhang, Y He, L Liu - The Journal of Headache and Pain, 2024 - Springer
Background Currently, the treatment and prevention of migraine remain highly challenging.
Mendelian randomization (MR) has been widely used to explore novel therapeutic targets …

Ischemic stroke demographics, clinical features and scales and their correlations: an exploratory study from Jordan

KZ Alawneh, MA Qawasmeh, LA Raffee… - Future Science …, 2022 - Future Science
Aims: The authors aimed to assess the ischemic stroke risk factors and scales. Materials &
methods: A retrospective cohort study was conducted on patients with acute ischemic stroke …