Emerging role of carbonic anhydrase inhibitors
CT Supuran - Clinical Science, 2021 - portlandpress.com
Inhibition of carbonic anhydrase (CA, EC 4.2. 1.1) was clinically exploited for decades, as
most modern diuretics were obtained considering as lead molecule acetazolamide, the …
most modern diuretics were obtained considering as lead molecule acetazolamide, the …
A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation
CT Supuran - Bioorganic & Medicinal Chemistry Letters, 2023 - Elsevier
Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …
are presented, with an emphasis on the deciphering of the activation mechanism, the …
Cyclic Peptide Screening Methods for Preclinical Drug Discovery: Miniperspective
X Li, TW Craven, PM Levine - Journal of Medicinal Chemistry, 2022 - ACS Publications
Cyclic peptides are among the most diverse architectures for current drug discovery efforts.
Their size, stability, and ease of synthesis provide attractive scaffolds to engage and …
Their size, stability, and ease of synthesis provide attractive scaffolds to engage and …
The therapeutic importance of acid-base balance
BN Quade, MD Parker, R Occhipinti - Biochemical pharmacology, 2021 - Elsevier
Baking soda and vinegar have been used as home remedies for generations and today we
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …
Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors
Alzheimer's disease (AD) is a complex, predominant, and progressive form of dementia. The
treatment of AD alters depending on the cognitive and behavioral symptoms. The utility of …
treatment of AD alters depending on the cognitive and behavioral symptoms. The utility of …
Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery
CT Supuran - Expert opinion on drug discovery, 2020 - Taylor & Francis
Introduction The spacious active site cavity of the metalloenzyme carbonic anhydrase (CA,
EC 4.2. 1.1) shows a great versatility for a variety of binding modes for modulators of activity …
EC 4.2. 1.1) shows a great versatility for a variety of binding modes for modulators of activity …
Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA) Cerebrovascular disease and the failure of elimination of …
Two of the key functions of arteries in the brain are (1) the well‐recognized supply of blood
via the vascular lumen and (2) the emerging role for the arterial walls as routes for the …
via the vascular lumen and (2) the emerging role for the arterial walls as routes for the …
Understanding the antioxidant and carbonyl sequestering activity of carnosine: Direct and indirect mechanisms
Carnosine is an endogenous dipeptide whose oral administration has been found to prevent
several oxidative based diseases including lung disease, type 2 diabetes and its micro and …
several oxidative based diseases including lung disease, type 2 diabetes and its micro and …
Endothelial response to glucose: dysfunction, metabolism, and transport
AM Clyne - Biochemical Society Transactions, 2021 - portlandpress.com
The endothelial cell response to glucose plays an important role in both health and disease.
Endothelial glucose-induced dysfunction was first studied in diabetic animal models and in …
Endothelial glucose-induced dysfunction was first studied in diabetic animal models and in …
Dissecting the crosstalk between endothelial mitochondrial damage, vascular inflammation, and neurodegeneration in cerebral amyloid angiopathy and Alzheimer's …
Alzheimer's disease (AD) is the most prevalent cause of dementia and is pathologically
characterized by the presence of parenchymal senile plaques composed of amyloid β (Aβ) …
characterized by the presence of parenchymal senile plaques composed of amyloid β (Aβ) …