Sertoli cell immune regulation: a double-edged sword

RL Washburn, T Hibler, G Kaur, JM Dufour - Frontiers in Immunology, 2022 - frontiersin.org
The testis must create and maintain an immune privileged environment to protect maturing
germ cells from autoimmune destruction. The establishment of this protective environment is …

Characterization of rodent Sertoli cell primary cultures

HD Zomer, PP Reddi - Molecular reproduction and …, 2020 - Wiley Online Library
Sertoli cells play a vital role in spermatogenesis by offering physical and nutritional support
to the differentiating male germ cells. They form the blood–testis barrier and secrete growth …

Bilateral striatal transplantation of human olfactory stem cells ameliorates motor function, prevents necroptosis-induced cell death and improves striatal volume in the …

AH Bayat, S Saeidikhoo, V Ebrahimi, S Mesgar… - Journal of Chemical …, 2021 - Elsevier
Cellular transplant therapy is one of the most common therapeutic strategies used to
mitigate symptoms of neurodegenerative diseases such as Huntington's disease (HD) …

Therapeutic application of Sertoli cells for treatment of various diseases

RL Washburn, T Hibler, LA Thompson, G Kaur… - Seminars in Cell & …, 2022 - Elsevier
Sertoli cells (SCs) are immune privileged cells found in the testis that function to
immunologically protect maturing germ cells from immune destruction. This immune …

Modulation of adenosine signaling reverses 3-nitropropionic acid-induced bradykinesia and memory impairment in adult zebrafish

MT Wiprich, S Altenhofen, D Gusso… - Progress in Neuro …, 2022 - Elsevier
Huntington's disease (HD) is a neurodegenerative disorder, characterized by motor
dysfunction, psychiatric disturbance, and cognitive decline. In the early stage of HD, occurs a …

Bone marrow mesenchymal stem cell condition medium loaded on PCL nanofibrous scaffold promoted nerve regeneration after sciatic nerve transection in male rats

A Raoofi, Y Sadeghi, A Piryaei, E Sajadi… - Neurotoxicity …, 2021 - Springer
Nowadays, researchers pay a vast deal of attention to neural tissue regeneration due to its
tremendous effect on the patient's life. There are many strategies, from using conventional …

Dental pulp stem cell transplantation ameliorates motor function and prevents cerebellar atrophy in rat model of cerebellar ataxia

A Aliaghaei, ME Boroujeni, H Ahmadi, AH Bayat… - Cell and tissue …, 2019 - Springer
Cerebellar ataxias (CA) include a range of neurodegenerative disorders hallmarked by
deterioration of the cerebellum. Cell replacement therapy (CRT) offers a potential remedy for …

Grafted Sertoli cells prevent neuronal cell death and memory loss induced by seizures

M Mehranpour, M Sani, A Beirami… - Metabolic Brain …, 2023 - Springer
Epilepsy significantly reduces the patient's quality of life, and we still need to develop new
therapeutic approaches to control it. Transplantation of cells such as Sertoli cells (SCs) …

Pharmacological mechanism of immunomodulatory agents for the treatment of severe cases of COVID-19 infection

Z Bahari, Z Jangravi, H Ghoshooni, MR Afarinesh… - Inflammation …, 2021 - Springer
Abstract Objective Coronavirus disease 2019 (COVID-19) is a world-wide pandemic caused
by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To date, treatment of …

Therapeutics effects of [Pyr1] apelin-13 on rat contusion model of spinal cord injury: An experimental study

S Vafaei-Nezhad, S Niknazar, M Norouzian… - Journal of Chemical …, 2021 - Elsevier
Spinal cord injury (SCI) can cause various symptoms, including pain, complete or
incomplete loss of autonomic, sensory, motor and functions inferior to the site of the damage …