The cricket paralysis virus (CrPV), a member of the CrPV-like virus family, contains a single
positive-stranded RNA genome that encodes two non-overlapping open reading frames …

Internal initiation of protein synthesis in eukaryotes is accomplished by recruitment of
ribosomes to structured internal ribosome entry sites (IRESs), which are located in certain …

To provide a bridge between in vivo and in vitro studies of eukaryotic translation initiation,
we have developed a reconstituted translation initiation system using components from the …

Adenine quantitation is required for a variety of applications. To date, the prevalent method
for quantifying free adenine, in a variety of applications, is the detection of fluorescent …

Endoplasmic reticulum (ER) stress is associated with the functional disorder of the ER.
During conditions of ER stress, cells induce at least two responses to maintain ER function …

Previous analyses of complexes of 40S ribosomal subunits with the hepatitis C virus (HCV)
internal ribosome entry site (IRES) have revealed contacts made by the IRES with ribosomal …

The endoplasmic reticulum (ER) is a nexus for mRNA localization and translation, and
recent studies have demonstrated that ER-bound ribosomes also play a transcriptome-wide …

13-Deoxytedanolide is a potent antitumor macrolide isolated from the marine sponge
Mycale adhaerens. In spite of its remarkable activity, the mode of action of 13 …

Ribosomes are key macromolecular protein synthesis machineries in the cell. Human
ribosomes have so far not been studied to atomic resolution because of their particularly …

This study is centred upon an important biological problem concerning the structural
organization of mammalian ribosomes that cannot be studied by X-ray analysis because …