Going back to their discovery in the early 1980s, both the Human T-cell Leukemia virus type-
1 (HTLV-1) and the Human Immunodeficiency Virus type-1 (HIV-1) greatly fascinated the …

Since the discovery of the human T-cell leukemia virus-1 (HTLV-1), cellular and animal
models have provided invaluable contributions in the knowledge of viral infection …

Bioavailable and less toxic synthetic retinoids, such as the atypical adamantyl retinoid
ST1926, have been well developed and investigated in clinical trials for many diseases. The …

Highlights•Molecular mechanisms of HTLV-1 oncogenesis.•Innate and acquired immune
response to HTLV-1.•Clonality of HTLV-1 in vivo.•We bring together the host and viral factors …

Vitamin A and its derivatives, the retinoids, are micronutrient necessary for the human diet in
order to maintain several cellular functions from human development to adulthood and also …

Breast cancer is a global health concern, with increasing disease burden and disparities in
access to healthcare. Late diagnosis and limited treatment options in underserved areas …

Background Adult T-cell leukemia (ATL) is an aggressive neoplasm caused by human T-cell
leukemia virus type 1 (HTLV-1). ATL carries a poor prognosis due to chemotherapy …

Background Exosomes are membrane nano-vesicles secreted by a multitude of cells that
harbor biological constituents such as proteins, lipids, mRNA and microRNA. Exosomes can …

Sphingolipid-mediated regulation in cancer development and treatment is largely ceramide-
centered with the complex sphingolipid metabolic pathways unfolding as attractive targets …

Human T-cell lymphotropic virus type 1 (HTLV-1) infection is linked to adult T-cell leukemia-
lymphoma (ATLL) and HTLV-I-associated myelopathy/tropical spastic paraparesis …