Phosphoinositides (PIs) are phospholipids derived from phosphatidylinositol. PIs are
regulated via reversible phosphorylation, which is directed by the opposing actions of PI …

Primary cilia act as cell surface antennae, coordinating cellular responses to sensory inputs
and signalling molecules that regulate developmental and homeostatic pathways. Cilia are …

Phosphoinositides (PIs) are lipid signaling molecules that operate by recruiting proteins to
cellular membranes via PI recognition domains. The dominant PI of the plasma membrane is …

Activation of hepatic stellate cells (HSCs) plays a critical role in liver fibrosis. However, the
molecular basis for HSC activation remains poorly understood. Herein, we demonstrate that …

The primary cilium is a nexus for cell signaling and relies on specific protein trafficking for
function. The tubby family protein TULP3 transports integral membrane proteins into cilia …

Primary cilia play counterregulatory roles in cystogenesis—they inhibit cyst formation in the
normal renal tubule but promote cyst growth when the function of polycystins is impaired …

Abstract Background and Aims Autosomal dominant polycystic liver and kidney disease is a
spectrum of hereditary diseases, which display disturbed function of primary cilia leading to …

DNA lesions that evade repair can lead to mutations that drive the development of cancer,
and cellular responses to DNA damage can trigger senescence and cell death, which are …

Exome sequencing (ES) has been used in a variety of clinical settings but there are limited
data on its utility for diagnosis and/or prediction of monogenic liver diseases. We developed …

Background According to data from large national registries, almost 20%–25% of patients
with end-stage kidney disease have an undetermined kidney disease (UKD). Recent data …