Background: The sudden and drastic changes due to the Coronavirus Disease 19 (COVID-
19) pandemic have impacted people's physical and mental health. Clinically-vulnerable …

Loneliness is associated with increased morbidity and mortality. Deeper understanding of
neurobiological mechanisms underlying loneliness is needed to identify potential …

Background and Objectives To investigate the independent associations of social isolation
and loneliness with incident dementia and to explore the potential neurobiological …

Alzheimer's disease (AD) is the most common chronic disease in the elderly, with a high
incidence rate. In recent years, deep learning has become popular in the field of medical …

Loneliness can be operationalized as the actual or perceived absence of those social
relationships that serve to meet basic emotional needs. In contrast to solitude, a chosen …

In social species such as humans, non-human primates, and even many rodent species,
social interaction and the maintenance of social bonds are necessary for mental and …

Introduction The relationship between persistent loneliness and Alzheimer's disease (AD) is
unclear. We examined the relationship between different types of mid‐life loneliness and the …

Loneliness has been defined as an agonizing encounter, experienced when the need for
human intimacy is not met adequately, or when a person's social network does not match …

Social health factors (eg, social activities or social support) and cognitive activity
engagement have been associated with dementia risk, but their neural substrates have not …

Background: Loneliness has drawn increasing attention over the past few decades due to
rising recognition of its close connection with serious health issues, like dementia. Yet …