The Na+, K+-ATPase is a ubiquitous membrane transport protein in mammalian cells,
responsible for establishing and maintaining high K+ and low Na+ in the cytoplasm required …

Maintaining the proper balance between cell apoptosis and proliferation is required for
normal tissue homeostasis; when this balance is disrupted, disease such as pulmonary …

Transporting epithelia posed formidable conundrums right from the moment that Du Bois
Raymond discovered their asymmetric behavior, a century and a half ago. It took a century …

Background Glioblastoma multiforme (GBM) is very difficult to treat with conventional anti-
cancer/anti-apoptotic drugs. We tested the hypothesis that inhibition of Na+/K+-ATPase …

Stimulus-dependent elevation of intracellular Ca2+ ([Ca2+] i) affects the expression of
numerous genes–a phenomenon known as excitation-transcription coupling. Recently, we …

It is generally accepted that electrochemical gradients of monovalent ions across the plasma
membrane, created by the coupled function of pumps, carriers and channels, are involved in …

Targeted elimination of senescent cells, senolysis, is one of the core trends in the anti-aging
therapy. Cardiac glycosides were recently proved to be a broad-spectrum senolytics. Here …

Cells lacking a stiff cell wall, eg, mammalian cells, must actively regulate their volume to
maintain proper cell function. On the time scale that protein production is negligible, water …

During severe influenza A virus (IAV) infections, a large amount of damage to the pulmonary
epithelium is the result of the antiviral immune response. Specifically, whilst CD8+ T cells …

Cytoplasm is thought to have many hydrogel-like characteristics, including the ability to
absorb large amounts of water and change volume in response to alterations in external …