Inflammation is strictly associated with cancer and plays a key role in tumor development
and progression. Several epidemiological studies have demonstrated that inflammation can …

Chemokines are a large family of small chemotactic cytokines that coordinates immune cell
trafficking. In cancer, they have a pivotal role in the migration pattern of immune cells into the …

Solid tumors consist of neoplastic cells, non-malignant stromal cells, and migratory
hematopoietic cells. Complex interactions between the cell types in this microenvironment …

A complex network of chemokines and their receptors influences the development of primary
tumours and metastases. New information about the biological role of chemokines in these …

The use of various transgenic mouse models and analysis of human tumour biopsies has
shown that bone marrow-derived myeloid cells, such as macrophages, neutrophils …

The mechanisms responsible for recruiting monocytes from the bloodstream into solid
tumors are now well characterized. However, recent evidence has shown that these cells …

Chemokines are critical mediators of cell migration during routine immune surveillance,
inflammation, and development. Chemokines bind to G protein–coupled receptors and …

Malignant cells from at least 23 different types of cancer express the chemokine receptor
CXCR4 and respond to its ligand CXCL12. This receptor ligand pair appears to be involved …

Constitutive expression of the inflammatory cytokine tumor necrosis factor-α (TNF-α) is
characteristic of malignant ovarian surface epithelium. We investigated the hypothesis that …

Tumor-associated macrophages (TAM) may have tumor-promoting activity, but it is not clear
how their phenotype is achieved. In this study, we demonstrate that ovarian cancer cells …