The T cell immune response against SARS-CoV-2

P Moss - Nature immunology, 2022 - nature.com
The adaptive immune response is a major determinant of the clinical outcome after SARS-
CoV-2 infection and underpins vaccine efficacy. T cell responses develop early and …

Activation or exhaustion of CD8+ T cells in patients with COVID-19

MS Rha, EC Shin - Cellular & molecular immunology, 2021 - nature.com
In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …

Signature of long-lived memory CD8+ T cells in acute SARS-CoV-2 infection

S Adamo, J Michler, Y Zurbuchen, C Cervia… - Nature, 2022 - nature.com
Immunological memory is a hallmark of adaptive immunity and facilitates an accelerated and
enhanced immune response upon re-infection with the same pathogen,. Since the outbreak …

Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states

TR Müller, T Sekine, D Trubach, J Niessl… - Science translational …, 2023 - science.org
Suboptimal immunity to SARS-CoV-2 mRNA vaccination has frequently been observed in
individuals with various immunodeficiencies. Given the increased antibody evasion …

Adaptive immune responses and immunity to SARS-CoV-2

D Primorac, K Vrdoljak, P Brlek, E Pavelić… - Frontiers in …, 2022 - frontiersin.org
Since the onset of the COVID-19 pandemic, the medical field has been forced to apply the
basic knowledge of immunology with the most up-to-date SARS-CoV-2 findings and …

Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children

Q Xu, P Milanez-Almeida, AJ Martins, AJ Radtke… - Nature …, 2023 - nature.com
Most studies of adaptive immunity to SARS-CoV-2 infection focus on peripheral blood, which
may not fully reflect immune responses at the site of infection. Using samples from 110 …

Post-pandemic memory T cell response to SARS-CoV-2 is durable, broadly targeted, and cross-reactive to the hypermutated BA. 2.86 variant

R Nesamari, MA Omondi, R Baguma, MA Höft… - Cell host & …, 2024 - cell.com
Ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution has
given rise to recombinant Omicron lineages that dominate globally (XBB. 1), as well as the …

Beschlussentwurf der STIKO zur 4. Aktualisierung der COVID-19-Impfempfehlung und die dazugehörige wissenschaftliche Begründung

S Vygen-Bonnet, J Koch, C Bogdan, T Harder… - 2021 - edoc.rki.de
Die STIKO empfiehlt die Impfung gegen COVID-19 mit einem der beiden zugelassenen
mRNA-Impfstoffe (Comirnaty von BioNTech/Pfizer, COVID-19-Vaccine von Moderna) oder …

T cell-oriented strategies for controlling the COVID-19 pandemic

JY Noh, HW Jeong, JH Kim, EC Shin - Nature Reviews Immunology, 2021 - nature.com
COVID-19 vaccination programmes are ongoing worldwide. Neutralizing antibodies are
thought to be key for host protection against COVID-19; however, strategies that focus only …

The robustness of cellular immunity determines the fate of SARS-CoV-2 infection

E Moga, E Lynton-Pons, P Domingo - Frontiers in immunology, 2022 - frontiersin.org
Two years after the appearance of the SARS-CoV-2 virus, the causal agent of the current
global pandemic, it is time to analyze the evolution of the immune protection that infection …