The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics

L Qian, X Lin, X Gao, RU Khan, JY Liao, S Du… - Chemical …, 2023 - ACS Publications
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

[HTML][HTML] Cell-penetrating peptides in protein mimicry and cancer therapeutics

M Zorko, S Jones, Ü Langel - Advanced drug delivery reviews, 2022 - Elsevier
Extensive research has been undertaken in the pursuit of anticancer therapeutics. Many
anticancer drugs require specificity of delivery to cancer cells, whilst sparing healthy tissue …

Targeted intracellular delivery of antibodies: the state of the art

TA Slastnikova, AV Ulasov, AA Rosenkranz… - Frontiers in …, 2018 - frontiersin.org
A dominant area of antibody research is the extension of the use of this mighty experimental
and therapeutic tool for the specific detection of molecules for diagnostics, visualization, and …

Cell-penetrating peptide: a means of breaking through the physiological barriers of different tissues and organs

J Xu, AR Khan, M Fu, R Wang, J Ji, G Zhai - Journal of Controlled Release, 2019 - Elsevier
The selective infiltration of cell membranes and tissue barriers often blocks the entry of most
active molecules. This natural defense mechanism prevents the invasion of exogenous …

Hepatitis B viral protein HBx and the molecular mechanisms modulating the hallmarks of hepatocellular carcinoma: a comprehensive review

E Sivasudhan, N Blake, Z Lu, J Meng, R Rong - Cells, 2022 - mdpi.com
With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the
most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X …

Relevance of HBx for hepatitis B virus-associated pathogenesis

A Schollmeier, M Glitscher, E Hildt - International Journal of Molecular …, 2023 - mdpi.com
The hepatitis B virus (HBV) counts as a major global health problem, as it presents a
significant causative factor for liver-related morbidity and mortality. The development of …

mRNA as novel technology for passive immunotherapy

T Schlake, A Thess, M Thran, I Jordan - Cellular and Molecular Life …, 2019 - Springer
While active immunization elicits a lasting immune response by the body, passive
immunotherapy transiently equips the body with exogenously generated immunological …

[HTML][HTML] Potential of cell-penetrating peptides (CPPs) in delivery of antiviral therapeutics and vaccines

I Sadeghian, R Heidari, S Sadeghian, MJ Raee… - European Journal of …, 2022 - Elsevier
Viral infections are a great threat to human health. Currently, there are no effective vaccines
and antiviral drugs against the majority of viral diseases, suggesting the need to develop …

[HTML][HTML] Roles of long non-coding RNAs and emerging RNA-binding proteins in innate antiviral responses

Y Wang, Y Wang, W Luo, X Song, L Huang, J Xiao… - Theranostics, 2020 - ncbi.nlm.nih.gov
The diseases caused by viruses posed a great challenge to human health, the development
of which was driven by the imbalanced host immune response. Host innate immunity is an …

Intracellular delivery of therapeutic antibodies into specific cells using antibody-peptide fusions

J Gaston, N Maestrali, G Lalle, M Gagnaire… - Scientific reports, 2019 - nature.com
Because of their favorable properties as macromolecular drugs, antibodies are a very
successful therapeutic modality for interfering with disease-relevant targets in the …