Multiscale systems biology and systems pharmacology are powerful methodologies that are
playing increasingly important roles in understanding the fundamental mechanisms of …

Biologically related processes operate across multiple spatiotemporal scales. For
computational modeling methodologies to mimic this biological complexity, individual scale …

We present a new approach to the study of the immune system that combines techniques of
systems biology with information provided by data-driven prediction methods. To this end …

Macrophages derived from monocyte precursors undergo specific polarization processes
which are influenced by the local tissue environment: classically activated (M1) …

The immune system is able to respond more vigorously to the second contact with a given
antigen than to the first contact. Vaccination protocols generally include at least two doses …

Aging is a biological process characterized by the progressive functional decline of many
interrelated physiological systems. In particular, aging is associated with the development of …

Vertebrates are constantly exposed to pathogens, and the adaptive immunity has most likely
evolved to control and clear such infectious agents. CD4+ T cells are the major players in …

Background Inflammation is a highly complex biological response evoked by many stimuli. A
persistent challenge in modeling this dynamic process has been the (nonlinear) nature of …

It is coming nowadays more clear that in order to obtain a unified description of the different
mechanisms governing the behavior and causality relations among the various parts of a …

Bromelain has been used for treatment of inflammatory diseases for decades. However, the
exact mechanism of action remains poorly understood. While in vitro investigations have …