Immunobiology and pathogenesis of hepatitis B virus infection

M Iannacone, LG Guidotti - Nature Reviews Immunology, 2022 - nature.com
Hepatitis B virus (HBV) is a non-cytopathic, hepatotropic virus with the potential to cause a
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …

Meta‐analysis: chemoprevention of hepatocellular carcinoma with statins, aspirin and metformin

RW Zeng, JN Yong, DJH Tan, CE Fu… - Alimentary …, 2023 - Wiley Online Library
Background Emerging data suggest that statins, aspirin and metformin may protect against
hepatocellular carcinoma (HCC) development. However, prior meta‐analyses were limited …

Metformin reduces hepatocellular carcinoma incidence after successful antiviral therapy in patients with diabetes and chronic hepatitis C in Taiwan

PC Tsai, HT Kuo, CH Hung, KC Tseng, HC Lai… - Journal of …, 2023 - Elsevier
Background & Aims Diabetes mellitus (DM) is known to increase the risk of hepatocellular
carcinoma (HCC) among individuals with chronic hepatitis C (CHC). We aimed to evaluate …

Systematic review with meta‐analysis: The effects of non‐steroidal anti‐inflammatory drugs and anti‐platelet therapy on the incidence and recurrence of …

RZH Tan, I Lockart, C Abdel Shaheed… - Alimentary …, 2021 - Wiley Online Library
Summary Background Chemoprevention with NSAIDs, including aspirin, and anti‐platelet
therapy (APT), has been suggested to reduce the incidence and recurrence of …

Aspirin in hepatocellular carcinoma

E Ricciotti, KJ Wangensteen, GA FitzGerald - Cancer research, 2021 - AACR
Preclinical and clinical studies provide evidence for aspirin as a preventative agent for
cancer. Compelling direct evidence supports a chemopreventive effect of aspirin in …

Blockade of ampk-mediated camp–pka–creb/atf1 signaling synergizes with aspirin to inhibit hepatocellular carcinoma

H Zhang, S Yang, J Wang, Y Jiang - Cancers, 2021 - mdpi.com
Simple Summary Epidemiological and experimental studies have demonstrated that aspirin
(acetylsalicylic acid) may prevent the incidence of some types of human cancer, including …

[HTML][HTML] Therapeutic mechanisms and beneficial effects of non-antidiabetic drugs in chronic liver diseases

HA Lee, Y Chang, PS Sung, EL Yoon… - Clinical and …, 2022 - ncbi.nlm.nih.gov
The global burden of chronic liver disease (CLD) is substantial. Due to the limited indication
of and accessibility to antiviral therapy in viral hepatitis and lack of effective pharmacological …

Biochemical and pathophysiological improvements in rats with thioacetamide induced-hepatocellular carcinoma using aspirin plus vitamin C

RR El Sadda, ZR Elshahawy, EA Saad - BMC cancer, 2023 - Springer
Background Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related
death, so we should be concerned and look for effective/less-harmful treatments than …

Postoperative adjuvant aspirin for patients with hepatitis B virus-related hepatocellular carcinoma and portal vein tumor thrombus: An open-label, randomized …

CD Lu, YB Jiang, JK Feng, L Wang, XB Wei, B Zhou… - Heliyon, 2023 - cell.com
Purpose To compare the survival outcomes of postoperative adjuvant aspirin with surgery
alone in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and …

[HTML][HTML] Statin and aspirin for chemoprevention of hepatocellular carcinoma: Time to use or wait further?

MJ Goh, DH Sinn - Clinical and Molecular Hepatology, 2022 - ncbi.nlm.nih.gov
Preclinical studies highlighted potential therapeutic applications of aspirin and statins as
anticancer agents based on their pleiotropic effects. Epidemiologic studies suggested the …