Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS)
is a form of thrombotic microangiopathy secondary to an infection by an enterohemorrhagic …

Objectives Coxiella and Bartonella spp. display particular tropism for endothelial or endocardial
tissues and an abnormal host response to infections with induced autoimmunity. We …

The anti–von Willebrand factor nanobody caplacizumab was licensed for adults with
immune-mediated thrombotic thrombocytopenic purpura (iTTP) based on prospective controlled …

Objective To evaluate the clinical course of and risk factors for arterial thrombotic events in
adult inpatients with coronavirus disease 2019 (COVID-19). Methods All consecutive adult …

Background Long-term outcomes after multiple courses of rituximab among children with
frequently relapsing, steroid-dependent nephrotic syndrome (FRSDNS) are unknown. Methods …

Purpose Primary hyperoxaluria type 1 (PH1) is a rare, progressive, genetic disease with
limited treatment options. We report the efficacy and safety of lumasiran, an RNA interference …

Rituximab is an effective treatment for steroid-dependent/ frequently-relapsing nephrotic
syndrome (SDFRNS) in children. However, the optimal rituximab regimen remains unknown. To …

Autosomal recessive polycystic kidney disease (ARPKD) is a severe disease of early
childhood that is clinically characterized by fibrocystic changes of the kidneys and the liver. The …

Although splenectomy is still considered the most effective curative treatment for immune
thrombocytopenia (ITP), its use has significantly declined in the last decade, especially since …

Background Steroid-sensitive nephrotic syndrome (SSNS) is, in most patients, a chronic
disease with 80% experiencing at least one relapse after first flare. B cell depletion using …