Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …

The efficiency, selectivity and sustainability benefits offered by enzymes are enticing
chemists to consider biocatalytic transformations to complement or even supplant more …

Conspectus Despite the astonishing diversity of naturally occurring biocatalytic processes,
enzymes do not catalyze many of the transformations favored by synthetic chemists. Either …

Directed evolution of stereo‐, regio‐, and chemoselective enzymes constitutes a unique way
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …

The ability of one enzyme to catalyse multiple, mechanistically distinct transformations likely
played a crucial role in organisms' abilities to adapt to changing external stimuli in the past …

Iron is an especially important redox-active cofactor in biology because of its ability to
mediate reactions with atmospheric O2. Iron-dependent oxygenases exploit this earth …

Hydroxylamine-derived reagents have enabled versatile nitrene transfer reactions for
introducing nitrogen-containing functionalities in small-molecule catalysis, as well as …

Aliphatic primary amines are prevalent in natural products, pharmaceuticals, and functional
materials. While a plethora of processes are reported for their synthesis, methods that …

Highlights•New-to-nature carbene and nitrene transfer enzymes inspired by chemical
catalysis.•Engineered hemoproteins that catalyze these transformations with high …

Electrophilic aminating reagents have seen a renaissance in recent years as effective
nitrogen sources for the synthesis of unprotected amino functionalities. Based on their …