Osteoarthritis (OA) can be regarded as a chronic, painful and degenerative disease that
affects all tissues of a joint and one of the major endpoints being loss of articular cartilage. In …

Further work on mediators and pathways that are common across different models and
occur in human osteoarthritis and that impact the osteoarthritis disease process at different …

Abstract Prostaglandin E2 (PGE2), a major cyclooxygenase-2 (COX-2) product, is highly
secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis (OA) …

Osteoarthritis (OA) is a whole joint disease, in which thinning and disappearance of cartilage
is a critical determinant in OA progression. The rupture of cartilage homeostasis whatever its …

Objective To examine the effect of different sources of Good Manufacturing Practice clinical
grade adipose‐derived mesenchymal stem cells (AD‐MSCs) on inflammatory factors in …

The matrix metalloproteinases (MMPs) play a crucial role in irreversible remodeling of the
extracellular matrix (ECM) in normal homeostasis and pathological states. Accumulating …

The large variety of biological functions governed by prostaglandin (PG) E2 is mediated by
signaling through four distinct E-type prostanoid (EP) receptors. The availability of mouse …

Cartilage damage is typically treated by chondrocyte transplantation, mosaicplasty, or
microfracture. Recent advances in tissue engineering have prompted research on …

Objective MicroRNAs (miRNAs) are endogenous small noncoding RNAs that regulate the
activity of target messenger RNAs (mRNAs) and cellular processes. MicroRNA‐451 (miR …

Introduction Adiponectin has been implicated in the pathogenesis of osteoarthritis (OA). We
studied the effects of adiponectin on the OA cartilage homeostasis. Methods …