Working toward the Future: Insights into Francisella tularensis Pathogenesis and Vaccine Development

RD Pechous, TR McCarthy… - … and molecular biology …, 2009 - Am Soc Microbiol
Francisella tularensis is a facultative intracellular gram-negative pathogen and the
etiological agent of the zoonotic disease tularemia. Recent advances in the field of …

Subversion of host recognition and defense systems by Francisella spp

CL Jones, BA Napier, TR Sampson… - Microbiology and …, 2012 - Am Soc Microbiol
Francisella tularensis is a Gram-negative intracellular pathogen and the causative agent of
the disease tularemia. Inhalation of as few as 10 bacteria is sufficient to cause severe …

Immunity to Francisella

SC Cowley, KL Elkins - Frontiers in microbiology, 2011 - frontiersin.org
In recent years, studies on the intracellular pathogen Francisella tularensis have greatly
intensified, generating a wealth of new information on the interaction of this organism with …

Proteomic characterization and functional analysis of outer membrane vesicles of Francisella novicida suggests possible role in virulence and use as a vaccine

T Pierson, D Matrakas, YU Taylor… - Journal of proteome …, 2011 - ACS Publications
We have isolated and characterized outer membrane vesicles (OMVs) from Francisella.
Transport of effector molecules through secretion systems is a major mechanism by which …

Identification of an Essential Francisella tularensis subsp. tularensis Virulence Factor

A Qin, DW Scott, JA Thompson, BJ Mann - Infection and immunity, 2009 - Am Soc Microbiol
Francisella tularensis, the highly virulent etiologic agent of tularemia, is a low-dose
intracellular pathogen that is able to escape from the phagosome and replicate in the …

Live Attenuated Tularemia Vaccines for Protection Against Respiratory Challenge With Virulent F. tularensis subsp. tularensis

Q Jia, MA Horwitz - Frontiers in cellular and infection microbiology, 2018 - frontiersin.org
Francisella tularensis is the causative agent of tularemia and a Tier I bioterrorism agent. In
the 1900s, several vaccines were developed against tularemia including the killed “Foshay” …

Live attenuated tularemia vaccines: recent developments and future goals

ME Marohn, EM Barry - Vaccine, 2013 - Elsevier
In the aftermath of the 2001 anthrax attacks in the US, numerous efforts were made to
increase the level of preparedness against a biological attack both in the US and worldwide …

Tularemia vaccine development: paralysis or progress?

R Sunagar, S Kumar, BJ Franz… - … development and therapy, 2016 - Taylor & Francis
Francisella tularensis (Ft) is a gram-negative intercellular pathogen and category A biothreat
agent. However, despite 15 years of strong government investment and intense research …

Tularemia vaccines: recent developments and remaining hurdles

JW Conlan - Future microbiology, 2011 - Taylor & Francis
Francisella tularensis subsp. tularensis is a facultative intracellular bacterial pathogen of
humans and other mammals. Its inhaled infectious dose is very low and can result in very …

Repression of inflammasome by Francisella tularensis during early stages of infection

RJ Dotson, SM Rabadi, EL Westcott, S Bradley… - Journal of Biological …, 2013 - ASBMB
Francisella tularensis is an important human pathogen responsible for causing tularemia. F.
tularensis has long been developed as a biological weapon and is now classified as a …