Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a
decade. Classically, scientists have tried to improve NM delivery by employing passive or …

The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …

The continuous growing, spreading, and metastasis of tumor cells depend on intercellular
communication within cells resident in a tissue environment. Such communication is …

Extracellular vesicles (EVs) are membrane enclosed micro-and nano-sized vesicles that are
secreted from almost every species, ranging from prokaryotes to eukaryotes, and from …

Local acidification of stroma is proposed to favour pre-metastatic niche formation but the
mechanism of initiation is unclear. We investigated whether Human Melanoma-derived …

Cancer-derived extracellular vesicles (EVs) have been detected in the bloodstream and
other biofluids of cancer patients. They carry various tumor-derived molecules such as …

Exosomes in blood play an important role in cell-to-cell signaling and are a novel source of
biomarkers for the diagnosis and prognosis of diseases. Recently, evidence has …

Extracellular vesicles (EVs) subtype, exosome is an extracellular nano-vesicle that sheds
from cells' surface and originates as intraluminal vesicles during endocytosis. Firstly, it was …

The tumor milieu is characteristically acidic as a consequence of the fermentative
metabolism of glucose that results in massive accumulation of lactic acid within the …

Lymph node metastasis is a crucial prognostic parameter in many different types of cancers
and a gateway for further dissemination to distant organs. Prior to metastatic dissemination …