Role of NRF2 in ovarian cancer

G Tossetta, S Fantone, E Montanari, D Marzioni… - Antioxidants, 2022 - mdpi.com
Among gynaecologic malignancies, ovarian cancer is one of the most dangerous, with a
high fatality rate and relapse due to the occurrence of chemoresistance. Many researchers …

Targeting the NRF2/KEAP1 pathway in cervical and endometrial cancers

G Tossetta, D Marzioni - European Journal of Pharmacology, 2023 - Elsevier
Cervical and endometrial cancers are among the most dangerous gynaecological
malignancies, with high fatality and recurrence rates due to frequent diagnosis at an …

MicroRNA-377: A therapeutic and diagnostic tumor marker

I Akhlaghipour, N Taghehchian, AS Zangouei… - International journal of …, 2023 - Elsevier
Cancer is considered as one of the main causes of human deaths globally. Despite the
recent progresses in therapeutic modalities, there is still a high rate of mortality among …

Immune evasion and drug resistance mediated by USP22 in cancer: novel targets and mechanisms

J Guo, J Zhao, W Fu, Q Xu, D Huang - Frontiers in immunology, 2022 - frontiersin.org
Regulation of ubiquitination is involved in various processes in cancer occurrence and
development, including cell cycle arrest, cell proliferation, apoptosis, invasion, metastasis …

MicroRNAs as the pivotal regulators of cisplatin resistance in head and neck cancers

F Tolue Ghasaban, A Maharati, AS Zangouei… - Cancer cell …, 2023 - Springer
Although, there is a high rate of good prognosis in early stage head and neck tumors, about
half of these tumors are detected in advanced stages with poor prognosis. A combination of …

PRC2 mediated KLF2 down regulation: a therapeutic and diagnostic axis during tumor progression

N Taghehchian, A Maharati, I Akhlaghipour… - Cancer Cell …, 2023 - Springer
Surgery and chemo-radiotherapy are used as the common first-line treatment options in
many cancers. However, tumor relapse is observed in many cancer patients following such …

Moving beyond cisplatin resistance: Mechanisms, challenges, and prospects for overcoming recurrence in clinical cancer therapy

R Fu, B Zhao, M Chen, X Fu, Q Zhang, Y Cui, X Hu… - Medical Oncology, 2023 - Springer
Cisplatin, a classical platinum-based chemotherapy agent, has been a frontline treatment for
various cancers for decades. However, its effectiveness has been hindered by the …

MicroRNAs as the critical regulators of autophagy-mediated cisplatin response in tumor cells

F Tolue Ghasaban, A Maharati, I Akhlaghipour… - Cancer Cell …, 2023 - Springer
Chemotherapy is one of the most common therapeutic methods in advanced and metastatic
tumors. Cisplatin (CDDP) is considered as one of the main first-line chemotherapy drugs in …

MicroRNAs as the critical regulators of forkhead box protein family in pancreatic, thyroid, and liver cancers

I Akhlaghipour, A Fanoodi, AS Zangouei… - Biochemical …, 2023 - Springer
The metabolism of human body is mainly regulated by the pancreas, liver, and thyroid using
the hormones or exocrine secretions that affect the metabolic processes from food digestion …

Molecular mechanisms of microRNA-301a during tumor progression and metastasis

AN Shad, A Fanoodi, A Maharati, I Akhlaghipour… - … -Research and Practice, 2023 - Elsevier
Cancer is known as one of the leading causes of human deaths globally. Late diagnosis is
considered as one of the main reasons for the high mortality rate among cancer patients …