Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

High-mobility group box 1 protein (HMGB1), which previously was thought to function only
as a nuclear factor that enhances transcription, was recently discovered to be a crucial …

Rapidly growing malignant tumors frequently encounter hypoxia and nutrient (eg, glucose)
deprivation, which occurs because of insufficient blood supply. This results in necrotic cell …

The immune system has evolved to respond not only to pathogens, but also to signals
released from dying cells. Cell death through necrosis induces inflammation, whereas …

High-mobility group box 1 protein (HMGB1), a chromatin associated nuclear protein and
extracellular damage associated molecular pattern molecule (DAMP), is an evolutionarily …

Damage-associated molecular patterns (DAMPs) are released in response to cell death and
stress, and are potent triggers of sterile inflammation. Recent evidence suggests that DAMPs …

Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms of
the gastrointestinal tract. Despite clinicopathological differences, GISTs share oncogenic KIT …

High mobility group box protein 1 (HMGB1) has been considered as a ubiquitous nuclear
protein with an architectural function, but even early reports have described its presence …

Purpose This review aimed to take stock of the current status of research on damage-
associated molecular pattern (DAMP) protein. We discuss the Janus-faced role of DAMP …

Mutually exclusive KIT and PDGFRA mutations are central events in GIST pathogenesis,
and their understanding is becoming increasingly important, because specific treatment …