Recent progress in the Horner-Wadsworth-Emmons reaction
JA Bisceglia, LR Orelli - Current Organic Chemistry, 2015 - ingentaconnect.com
The Horner-Wadsworth-Emmons reaction is one of the most reliable and widespread
synthetic tools for the stereocontrolled construction of ethylenic bonds. The versatility of the …
synthetic tools for the stereocontrolled construction of ethylenic bonds. The versatility of the …
Synthesis of monofluoroalkenes: a leap forward
M Drouin, JD Hamel, JF Paquin - Synthesis, 2018 - thieme-connect.com
Monofluoroalkenes have found wide application in organic chemistry, medicinal chemistry,
and materials science. This review summarizes the most recent advances made regarding …
and materials science. This review summarizes the most recent advances made regarding …
Horner–Wadsworth–Emmons reaction as an excellent tool in the synthesis of fluoro-containing biologically important compounds
M Bilska-Markowska, M Kaźmierczak - Organic & Biomolecular …, 2023 - pubs.rsc.org
Selective introduction of a double bond motif into a multifunctional organic compound is
always a big challenge. The Horner–Wadsworth–Emmons reaction is one of the most …
always a big challenge. The Horner–Wadsworth–Emmons reaction is one of the most …
A chemical tuned strategy to develop novel irreversible EGFR-TK inhibitors with improved safety and pharmacokinetic profiles
G Xia, W Chen, J Zhang, J Shao, Y Zhang… - Journal of Medicinal …, 2014 - ACS Publications
Gatekeeper T790 M mutation in EGFR is the most prevalent factor underlying acquired
resistance. Acrylamide-bearing quinazoline derivatives are powerful irreversible inhibitors …
resistance. Acrylamide-bearing quinazoline derivatives are powerful irreversible inhibitors …
Covalent EGFR inhibitors: binding mechanisms, synthetic approaches, and clinical profiles
M Hossam, DS Lasheen, KAM Abouzid - Archiv der Pharmazie, 2016 - Wiley Online Library
Being overexpressed in several types of cancer, the epidermal growth factor receptor
(EGFR) is considered one of the key therapeutic targets in oncology. Although many first …
(EGFR) is considered one of the key therapeutic targets in oncology. Although many first …
Synthesis of (E)‐α,β‐Unsaturated Thioesters from Malonic Acid Half Thioesters and Aldehydes
S Kawasaki, K Akagawa, K Kudo - Advanced Synthesis & …, 2023 - Wiley Online Library
A decarboxylative condensation of malonic acid half thioesters (MAHTs) with aldehydes
catalyzed by benzylammonium trifluoroacetate has been developed for the synthesis of (E) …
catalyzed by benzylammonium trifluoroacetate has been developed for the synthesis of (E) …
Identification and isolation of glucosytransferases (GT) expressed fungi using a two-photon ratiometric fluorescent probe activated by GT
L Feng, P Li, J Hou, YL Cui, XG Tian, ZL Yu… - Analytical …, 2018 - ACS Publications
As is well-known, fungi are an important biocatalysis model of glucosylation and have been
widely applied for bioactive compounds glucosylation mediated by the intracellular …
widely applied for bioactive compounds glucosylation mediated by the intracellular …
Copper-catalyzed ligand free ring-opening amination of gem-fluorohalocyclopropanes–An efficient route toward 2-fluoroallylamines
MA Novikov, YA Ibatov, NV Volchkov… - Journal of Fluorine …, 2017 - Elsevier
Ring-opening amination of gem-chlorofluoro-and gem-bromofluorocyclopropanes with
secondary alkyl, aryl amines or hydroxylamines catalyzed by copper (I) or copper (II) …
secondary alkyl, aryl amines or hydroxylamines catalyzed by copper (I) or copper (II) …
Copper (I)-catalyzed solvolysis of gem-chlorofluoro-and gem-bromofluorocyclopropanes. Preparation of 2-fluoroallylic ethers, esters and alcohols
MA Novikov, NV Volchkov, MB Lipkind… - Journal of Fluorine …, 2015 - Elsevier
Copper (I)-catalyzed solvolysis of gem-chlorofluoro-and gem-bromofluorocyclopropanes in
MeOH, NaOAc/AcOH, NaOAc/DMF, HCO 2 Na/HCO 2 H or water/dioxane affords 2 …
MeOH, NaOAc/AcOH, NaOAc/DMF, HCO 2 Na/HCO 2 H or water/dioxane affords 2 …
A new approach to the synthesis of (Z)-2-fluoro-2-alkenals via Wittig-type carbonyl condensation reactions of 2-(fluoromethyl)-4, 4, 6-trimethyl-1, 3-oxazine …
M Kajjout, M Smietana, J Leroy, C Rolando - Tetrahedron Letters, 2013 - Elsevier
We report here the transformation of aldehydes to their (Z)-α-fluoro-α, β-unsaturated
aldehyde homologs by condensation with the phosphonium salt of the Meyer's oxazine …
aldehyde homologs by condensation with the phosphonium salt of the Meyer's oxazine …