Classically, the CNS is described as displaying immune privilege, as it shows attenuated
responses to challenge by alloantigen. However, the CNS does show local inflammation in …

In the context of the only available vaccine (DENGVAXIA) that was marketed in several
countries, but poses higher risks to unexposed individuals, the development of antivirals for …

Abstract The development of High-Throughput Sequencing (HTS) technologies is having a
major impact on the genomic analysis of viral populations. Current HTS platforms can …

Porcine respiratory disease complex (PRDC), a common piglet disease, causes substantive
economic losses in pig farming. To investigate the viral diversity associated with PRDC, the …

Hepatitis C virus (HCV) is one of very few viruses that are either naturally cleared, or
alternatively persist to cause chronic disease. Viral diversity and escape, as well as host …

The fifth wave of the H7N9 influenza epidemic in China was distinguished by a sudden
increase in human infections, an extended geographic distribution, and the emergence of …

Background Diarrhoea is a major cause of death in neonate pigs and most of the viruses
that cause it are RNA viruses. Next Generation Sequencing (NGS) deeply characterize the …

Background Metagenome-assembled viral genomes have significantly advanced the
discovery and characterization of the human gut virome. However, we lack a comparative …

(1) Background: Over the last few years, there has been growing interest in the whole
genome sequencing (WGS) of rapidly mutating pathogens, such as influenza viruses (IVs) …

Longitudinal deep sequencing of viruses can provide detailed information about intra-host
evolutionary dynamics including how viruses interact with and transmit between hosts. Many …