[HTML][HTML] How much ischemia can the liver tolerate during resection?

WG van Riel, RF van Golen, MJ Reiniers… - … surgery and nutrition, 2016 - ncbi.nlm.nih.gov
The use of vascular inflow occlusion (VIO, also known as the Pringle maneuver) during liver
surgery prevents severe blood loss and the need for blood transfusion. The most commonly …

Protective mechanisms of hypothermia in liver surgery and transplantation

PB Olthof, MJ Reiniers, MC Dirkes, TM van Gulik… - Molecular …, 2015 - Springer
Hepatic ischemia/reperfusion (I/R) injury is a side effect of major liver surgery that often
cannot be avoided. Prolonged periods of ischemia put a metabolic strain on hepatocytes …

Preparation and practical applications of 2′, 7′-dichlorodihydrofluorescein in redox assays

MJ Reiniers, RF van Golen, S Bonnet… - Analytical …, 2017 - ACS Publications
Oxidative stress, a state in which intra-or extracellular oxidant production outweighs the
antioxidative capacity, lies at the basis of many diseases. DCFH2-DA (2′, 7 …

[HTML][HTML] Warm ischemia time-dependent variation in liver damage, inflammation, and function in hepatic ischemia/reperfusion injury

PB Olthof, RF van Golen, B Meijer, AA van Beek… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Background Hepatic ischemia/reperfusion (I/R) injury is characterized by hepatocellular
damage, sterile inflammation, and compromised postoperative liver function. Generally used …

[HTML][HTML] Metallated phthalocyanines and their hydrophilic derivatives for multi-targeted oncological photodynamic therapy

LM Dias, MJ de Keijzer, D Ernst, F Sharifi… - … of Photochemistry and …, 2022 - Elsevier
Background and aim A photosensitizer (PS) delivery and comprehensive tumor targeting
platform was developed that is centered on the photosensitization of key pharmacological …

CCL2–CCR2 signaling promotes hepatic ischemia/reperfusion injury

J Zhang, P Xu, P Song, H Wang, Y Zhang, Q Hu… - Journal of Surgical …, 2016 - Elsevier
Background Liver ischemia/reperfusion (I/R) injury is a type of uncontrolled inflammatory
cascade in which neutrophils, an early infiltrating immune cell population, elicit significant …

[HTML][HTML] The damage-associated molecular pattern HMGB1 is released early after clinical hepatic ischemia/reperfusion

RF van Golen, MJ Reiniers, G Marsman… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Objective and background Activation of sterile inflammation after hepatic
ischemia/reperfusion (I/R) culminates in liver injury. The route to liver damage starts with …

Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells

R Weijer, M Broekgaarden, RF van Golen, E Bulle… - BMC cancer, 2015 - Springer
Background Photodynamic therapy (PDT) of solid cancers comprises the administration of a
photosensitizer followed by illumination of the photosensitizer-replete tumor with laser light …

Trisulfate disaccharide decreases calcium overload and protects liver injury secondary to liver ischemia/reperfusion

ER Vasques, JEM Cunha, AMM Coelho… - PLoS …, 2016 - journals.plos.org
Background Ischemia and reperfusion (I/R) causes tissue damage and intracellular calcium
levels are a factor of cell death. Sodium calcium exchanger (NCX) regulates calcium …

[HTML][HTML] CCR2 dependent neutrophil activation and mobilization rely on TLR4-p38 axis during liver ischemia-reperfusion injury

P Xu, J Zhang, H Wang, G Wang… - American Journal of …, 2017 - ncbi.nlm.nih.gov
Liver ischemia-reperfusion injury (IRI) is a common clinical problem in which neutrophil
recruitment is an essential event. Our previous study revealed the important role of CC motif …