Gene expression is needed for the maintenance of heart function under normal conditions
and in response to stress. Each cell type of the heart has a specific program controlling …

A plethora of environmental and behavioral factors interact, resulting in changes in gene
expression and providing a basis for the development and progression of cardiovascular …

Background: Takotsubo syndrome (TTS) is characterized by an acute left ventricular
dysfunction and is associated with life-threating complications in the acute phase. The …

If unifying principles could be revealed for how the same genome encodes different
eukaryotic cells and for how genetic variability and environmental input are integrated to …

An important priority in the cardiovascular care of oncology patients is to reduce morbidity
and mortality, and improve the quality of life in cancer survivors through cross-disciplinary …

The temporal nature of chromatin structural changes underpinning pathologic transcription
are poorly understood. We measured chromatin accessibility and DNA methylation to study …

Precision-based molecular phenotyping of heart failure must overcome limited access to
cardiac tissue. Although epigenetic alterations have been found to underlie pathological …

Major depression is the most common mental disorder and a leading cause of years lived
with disability. In addition to the burden attributed to depressive symptoms and reduced daily …

Aims Natriuretic peptides are useful for diagnosis and prognostication of heart failure of any
cause. Now, research aims to discover novel biomarkers that will more specifically define …

Chronic heart failure (HF) is a leading clinical and public problem posing a higher risk of
morbidity and mortality in different populations. HF appears to be in both phenotypic forms …