Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Regulation of gene expression is achieved by sequence-specific transcriptional regulators,
which convey the information that is contained in the sequence of DNA into RNA …

SMYD3 is a methylase previously linked to cancer cell invasion and migration. Here we
show that SMYD3 favors TGFβ-induced epithelial–mesenchymal transition (EMT) in …

SMYD3 is a member of the SMYD lysine methylase family and plays an important role in the
methylation of various histone and non-histone targets. Aberrant SMYD3 expression …

Histone variants are chromatin components that replace replication-coupled histones in a
fraction of nucleosomes and confer particular characteristics to chromatin. H2A variants …

Histone methylation is an epigenetic change mediated by histone methyltransferase, and
has been connected to the beginning and progression of several diseases. The most …

Pancreatic cancer (PC) is an aggressive human cancer. Appropriate methods for the
diagnosis and treatment of PC have not been found at the genetic level, thus making …

Background: Epigenetic regulation has been verified as a key mechanism in tumorigenesis.
SET and MYND domain-containing protein 3 (SMYD3), a histone methyltransferase, is a …

Endothelial cell senescence is one of the main risk factors contributing to vascular diseases.
As increasing number of “epigenetic drugs” entering clinical trials, understanding the …

All cells are exposed to chemicals that can damage their nucleic acids. Cells must protect
these polymers because they code for key factors or complexes essential for life. Much of the …