Abstract Adenosine-to-inosine (A-to-I) editing is the most prevalent type of RNA editing in
humans, mediated by the adenosine deaminases acting on RNA (ADARs). Physiologically …

APOBEC3 enzymes contribute significantly to DNA mutagenesis in cancer. These enzymes
are also capable of converting C bases at specific positions of RNAs to U. However, the …

RNA editing is a post-transcriptional modification with a cell-specific manner and important
biological implications. Although single-cell RNA-seq (scRNA-seq) is an effective method for …

Abstract Adenosine-to-inosine (A-to-I) RNA editing, constituting nearly 90% of all RNA
editing events in humans, has been reported to contribute to the tumorigenesis in diverse …

Abstract A-to-I RNA editing, contributing to nearly 90% of all editing events in human, has
been reported to involve in the pathogenesis of Alzheimer's disease (AD) due to its roles in …

Non-coding RNAs occupy a significant fraction of the human genome. Their biological
significance is backed up by a plethora of emerging evidence. One of the most robust …

Abstract A-to-I RNA editing diversifies human transcriptome to confer its functional effects on
the downstream genes or regulations, potentially involving in neurodegenerative …

Parkinson's disease (PD) is characterized by dopaminergic neurodegeneration and an
abnormal accumulation of α-synuclein aggregates. A number of genetic factors have been …

Gastric cancer cases are often diagnosed at an advanced stage with poor prognosis.
Platinum-based chemotherapy has been internationally accepted as first-line therapy for …

Background RNA editing exerts critical impacts on numerous biological processes and thus
are implicated in crucial human phenotypes, including tumorigenesis and prognosis. While …