Osteocalcin (Ocn), which is specifically produced by osteoblasts, and is the most abundant
non-collagenous protein in bone, was demonstrated to inhibit bone formation and function …

Together, loss-and gain-of-function experiments have identified the bone-derived secreted
molecule osteocalcin as a hormone with a broad reach in rodents and primates. Following …

The novel Wuhan coronavirus (SARS-CoV-2) has been sequenced, and the virus shares
substantial similarity with SARS-CoV. Here, using a computational model of the spike …

The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone
cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on …

We present a supercomputer-driven pipeline for in silico drug discovery using enhanced
sampling molecular dynamics (MD) and ensemble docking. Ensemble docking makes use …

The strength of bone depends on bone quantity and quality. Osteocalcin (Ocn) is the most
abundant noncollagenous protein in bone and is produced by osteoblasts. It has been …

Abstracts Bone mainly functions as a supportive framework for the whole body and is the
major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing …

Osteoporosis associated with long-term glucocorticoid therapy remains a common and
serious bone disease. Additionally, in recent years it has become clear that more subtle …

Bone has traditionally been regarded as a static structural organ that supports movement of
the body and protects the internal organs. However, evidence has been accumulated in the …

Background Osteocalcin is the most abundant non-collagenous protein in bone and is
specifically expressed in osteoblasts. Previous studies using osteocalcin-deficient (Ocn–/–) …