As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in
organ development, epithelial homeostasis, tissue regeneration, wound healing and …

Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …

Fibrosis can develop in most organs and causes organ failure. The most common type of
lung fibrosis is known as idiopathic pulmonary fibrosis, in which fibrosis starts at the lung …

The lung is continuously exposed to particles, toxicants, and microbial pathogens that are
cleared by a complex mechanical, innate, and acquired immune system. Mucociliary …

Tissue fibrosis is a pathological condition that is associated with impaired epithelial repair
and excessive deposition of extracellular matrix (ECM). Fibrotic lesions increase the risk of …

Alveolar epithelium plays a pivotal role in protecting the lungs from inhaled infectious
agents. Therefore, the regenerative capacity of the alveolar epithelium is critical for recovery …

The transcriptional co-regulators YAP and TAZ pair primarily with the TEAD family of
transcription factors to elicit a gene expression signature that plays a prominent role in …