Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …

Purine nucleoside analogs (PNAs) compose a class of cytotoxic drugs that have played an
important role in the treatment of hematological neoplasms, especially lymphoid and …

During the last few years many Checkpoint kinase 1/2 (Chk1/Chk2) inhibitors have been
developed for the treatment of different type of cancers. In this study we evaluated the …

An epigenetic component, especially aberrant DNA methylation pattern, has been shown to
be frequently involved in sporadic breast cancer development. A growing body of literature …

Many antineoplastic nucleoside analogue-based combinatorial strategies focused on
remodelling aberrant DNA methylation patterns have been developed. The number of …

Common side effects of clofarabine (CFB) are liver toxicity, particularly a transient elevation
of transaminases and skin toxicity. We studied the correlation of pharmacokinetic (PK) …

Combination of cytostatic agents is a basic principle in the treatment of cancer. For the
treatment of acute myeloid leukemia (AML), purine analogs, like clofarabine and cytarabine …

A multistep synthesis of 2-chloro-9-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl) adenine
(clofarabine) is described from methyl β-D-ribofuranoside. A new improved method for …

To evaluate the time-and dose-dependent toxicity of clofarabine in mice and to further define
the chronotherapy strategy of it in leukemia, we compared the mortality rates, LD 50 s …

A multistep synthesis of 2-chloro-9-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl) adenine
(clofarabine) is described from methyl β-D-ribofuranoside. A new improved method for …