Perspectives on the Drosophila melanogaster Model for Advances in Toxicological Science

MD Rand, JM Tennessen, TFC Mackay… - Current …, 2023 - Wiley Online Library
The use of Drosophila melanogaster for studies of toxicology has grown considerably in the
last decade. The Drosophila model has long been appreciated as a versatile and powerful …

The Fetal Alcohol Spectrum Disorders—An Overview of Experimental Models, Therapeutic Strategies, and Future Research Directions

M Król, P Skowron, K Skowron, K Gil - Children, 2024 - mdpi.com
Since the establishment of a clear link between maternal alcohol consumption during
pregnancy and certain birth defects, the research into the treatment of FASD has become …

[HTML][HTML] Tsc2 coordinates neuroprogenitor differentiation

VA Riley, V Shankar, JC Holmberg, AM Sokolov… - Iscience, 2023 - cell.com
Neural stem cells (NSCs) of the ventricular-subventricular zone (V-SVZ) generate numerous
cell types. The uncoupling of mRNA transcript availability and translation occurs during the …

Functional assessment of homozygous ALDH18A1 variants reveals alterations in amino acid and antioxidant metabolism

MB Colonna, T Moss, S Mokashi… - Human molecular …, 2023 - academic.oup.com
Mono-and bi-allelic variants in ALDH18A1 cause a spectrum of human disorders associated
with cutaneous and neurological findings that overlap with both cutis laxa and spastic …

Deciphering the cellular heterogeneity of the insect brain with single‐cell RNA sequencing

X Wang, Y Zhai, H Zheng - Insect Science, 2024 - Wiley Online Library
Insects show highly complicated adaptive and sophisticated behaviors, including spatial
orientation skills, learning ability, and social interaction. These behaviors are controlled by …

Developmental alcohol exposure is exhausting: Sleep and the enduring consequences of alcohol exposure during development

DA Wilson, RM Sullivan, JF Smiley, M Saito… - Neuroscience & …, 2024 - Elsevier
Prenatal alcohol exposure is the leading nongenetic cause of human intellectual
impairment. The long-term impacts of prenatal alcohol exposure on health and well-being …

Modulation of the Drosophila transcriptome by developmental exposure to alcohol

TV Morozova, V Shankar, RA MacPherson… - BMC genomics, 2022 - Springer
Background Prenatal exposure to ethanol can cause fetal alcohol spectrum disorder
(FASD), a prevalent, preventable pediatric disorder. Identifying genetic risk alleles for FASD …

Insect Insights at the Single-Cell Level: Technologies and Applications

C Sun, Y Shao, J Iqbal - Cells, 2023 - mdpi.com
Single-cell techniques are a promising way to unravel the complexity and heterogeneity of
transcripts at the cellular level and to reveal the composition of different cell types and …

Synaptic Mechanisms of Ethanol Tolerance and Neuroplasticity: Insights from Invertebrate Models

A Bhandari, A Seguin, A Rothenfluh - International Journal of Molecular …, 2024 - mdpi.com
Alcohol tolerance is a neuroadaptive response that leads to a reduction in the effects of
alcohol caused by previous exposure. Tolerance plays a critical role in the development of …

The effects of methylphenidate and atomoxetine on Drosophila brain at single-cell resolution and potential drug repurposing for ADHD treatment

S Qu, X Zhou, Z Wang, Y Wei, H Zhou, X Zhang… - Molecular …, 2024 - nature.com
The stimulant methylphenidate (MPH) and the non-stimulant atomoxetine (ATX) are
frequently used for the treatment of attention-deficit/hyperactivity disorder (ADHD); however …