The pathogenesis of allergic diseases entails an ineffective tolerogenic immune response to
allergens. Regulatory T (Treg) cells play a key role in sustaining immune tolerance to …

The generation of regulatory T (T Reg) cells in the thymus is crucial for immune homeostasis
and self-tolerance. Recent discoveries have revealed the cellular and molecular …

The emerging notion of environment-induced reprogramming of Foxp3+ regulatory T (Treg)
cells into helper T (Th) cells remains controversial. By genetic fate mapping or adoptive …

On the whole, the healthy adaptive immune system is responsive to foreign antigens and
tolerant to self. However, many individual lymphocytes have, and even require, substantial …

Summary Foxp3+ regulatory T (Treg) cells limit inflammatory responses and maintain
immune homeostasis. Although comprised of several phenotypically and functionally distinct …

Regulatory T (Treg) cells play a vital role in the prevention of autoimmunity and the
maintenance of self‐tolerance, but these cells also have an active role in inhibiting immune …

We conducted a large-scale genetic analysis on giant cell arteritis (GCA), a polygenic
immune-mediated vasculitis. A case-control cohort, comprising 1,651 case subjects with …

Invading pathogens have unique molecular signatures that are recognized by Toll‐like
receptors (TLRs) resulting in either activation of antigen‐presenting cells (APCs) and/or …

An expanding spectrum of genetic defects that compromise T regulatory cell function
underlies human disorders of immune dysregulation and autoimmunity. Collectively, these …

The discovery that Bcl-6 was the transcriptional regulator of follicular helper T (Tfh) cells
completed the recognition of this population as an effector subset specialized in the …