Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects
C Li, P Jiang, S Wei, X Xu, J Wang - Molecular cancer, 2020 - Springer
Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …
Regulatory T cells and human disease
S Sakaguchi, N Mikami, JB Wing… - Annual review of …, 2020 - annualreviews.org
Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …
[HTML][HTML] Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity
K Hezaveh, RS Shinde, A Klötgen, MJ Halaby… - Immunity, 2022 - cell.com
The aryl hydrocarbon receptor (AhR) is a sensor of products of tryptophan metabolism and a
potent modulator of immunity. Here, we examined the impact of AhR in tumor-associated …
potent modulator of immunity. Here, we examined the impact of AhR in tumor-associated …
Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions
Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain
poorly understood. We analyze several thousand plasma proteins longitudinally in 306 …
poorly understood. We analyze several thousand plasma proteins longitudinally in 306 …
Next-generation regulatory T cell therapy
Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …
Targeting Treg cells in cancer immunotherapy
A Tanaka, S Sakaguchi - European journal of immunology, 2019 - Wiley Online Library
Foxp3‐expressing regulatory T (Treg) cells, which are indispensable for preventing
autoimmunity, also suppress effective tumor immunity. Treg cells abundantly infiltrate into …
autoimmunity, also suppress effective tumor immunity. Treg cells abundantly infiltrate into …
Human FOXP3+ regulatory T cell heterogeneity and function in autoimmunity and cancer
Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the
maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in …
maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in …
Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation
AJM Howden, JL Hukelmann, A Brenes, L Spinelli… - Nature …, 2019 - nature.com
Quantitative mass spectrometry reveals how CD4+ and CD8+ T cells restructure proteomes
in response to antigen and mammalian target of rapamycin complex 1 (mTORC1). Analysis …
in response to antigen and mammalian target of rapamycin complex 1 (mTORC1). Analysis …
Foxp3 post-translational modifications and Treg suppressive activity
G Deng, X Song, S Fujimoto, CA Piccirillo… - Frontiers in …, 2019 - frontiersin.org
Regulatory T cells (Tregs) are engaged in maintaining immune homeostasis and preventing
autoimmunity. Treg cells include thymic Treg cells and peripheral Treg cells, both of which …
autoimmunity. Treg cells include thymic Treg cells and peripheral Treg cells, both of which …
Regulatory T cell-specific epigenomic region variants are a key determinant of susceptibility to common autoimmune diseases
N Ohkura, Y Yasumizu, Y Kitagawa, A Tanaka… - Immunity, 2020 - cell.com
The contribution of FOXP3-expressing naturally occurring regulatory T (Treg) cells to
common polygenic autoimmune diseases remains ambiguous. Here, we characterized …
common polygenic autoimmune diseases remains ambiguous. Here, we characterized …