A significant growth of research in nanofluidics is achieved over the past decade, but the
field is still facing considerable challenges toward the transition from the current physics …

Nanofluidic structures have over the last two decades emerged as a powerful platform for
detailed analysis of DNA on the kilobase pair length scale. When DNA is confined to a …

The early steps of DNA double-strand break (DSB) repair in human cells involve the MRE11-
RAD50-NBS1 (MRN) complex and its cofactor, phosphorylated CtIP. The roles of these …

DNA confined to nanofluidic channels with a cross-section from tens to hundreds of nm wide
and hundreds of microns long stretches in an equilibrium process free of flow or end …

DNA double strand breaks (DSBs) can be detrimental to the cell and need to be efficiently
repaired. A first step in DSB repair is to bring the free ends in close proximity to enable …

Single DNA molecule techniques have revolutionized our understanding of DNA–protein
interactions. Traditional techniques for such studies have the major drawback that the DNA …

DNA–protein interactions are at the core of the cellular machinery and single molecule
methods have revolutionized the possibilities to study, and our understanding of these …

Genomic integrity depends on the RecA/RAD51 protein family. Discovered over five
decades ago with the founder bacterial RecA protein, eukaryotic RAD51 is an ATP …

Capturing the fast rotational motion of single nanoparticles has been hindered owing to the
difficulty of acquiring directional information under the optical diffraction limit. Here, we report …

Stretching of DNA in nanoscale confinement allows for several important studies. The
genetic contents of the DNA can be visualized on the single DNA molecule level, and the …