The discovery of regulated cell death presents tantalizing possibilities for gaining control
over the life–death decisions made by cells in disease. Although apoptosis has been the …

Accumulating evidence suggests that the reactive oxygen and nitrogen species are
generated in cardiomyocytes and endothelial cells during myocardial ischemia/reperfusion …

Dysregulation of nitric oxide (NO) and increased oxidative and nitrosative stress are
implicated in the pathogenesis of heart failure. Peroxynitrite is a reactive oxidant that is …

Atrial fibrillation (AF) and ischemic heart disease (IHD) represent the two most common
clinical cardiac diseases, characterized by angina, arrhythmia, myocardial damage, and …

Epigenetics is concerned about heritable changes in gene expression without alteration of
the coding sequence. Epigenetic modification of chromatin includes methylation of genomic …

Background—The role of the nitric oxide/cGMP/cGMP–dependent protein kinase G pathway
in myocardial protection and preconditioning has been the object of intensive investigations …

Poly (ADP-ribosylation) consists in the conversion of β-NAD+ into ADP-ribose, which is then
bound to acceptor proteins and further used to form polymers of variable length and …

PARP1, the major isoform of a family of ADP-ribosylating enzymes, has been implicated in
the regulation of various biological processes including DNA repair, gene transcription, and …

Poly (ADP-ribose) polymerase (PARP) comprise of a family of enzymes which catalyses poly
(ADPribosyl) ation of DNA-binding proteins. To date, seven isoforms have been identified …

Overactivation of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) contributes to
the development of cell dysfunction and tissue injury in various pathophysiological …