Metabolomics is a dynamic and emerging research field, similar to proteomics,
transcriptomics and genomics in affording global understanding of biological systems. It is …

The neuronal ceroid lipofuscinoses (NCL) are severe neurodegenerative lysosomal storage
disorders of childhood, characterized by accumulation of autofluorescent ceroid …

Metabolism has an essential role in biological systems. Identification and quantitation of the
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …

The gut microbiota has recently been identified as an environmental factor that may promote
metabolic diseases. To investigate the effect of gut microbiota on host energy and lipid …

In metabolomics, tissues typically are extracted by grinding in liquid nitrogen followed by the
stepwise addition of solvents. This is time-consuming and difficult to automate, and the …

Biological systems are increasingly being studied in a holistic manner, using omics
approaches, to provide quantitative and qualitative descriptions of the diverse collection of …

Metabolomic analysis of tissue samples can be applied across multiple fields including
medicine, toxicology, and environmental sciences. A thorough evaluation of several …

The fatal, primarily childhood neurodegenerative disorders, neuronal ceroid lipofuscinoses
(NCLs), are currently associated with mutations in 13 genes. The protein products of these …

Metabolomics, the omics science of biochemistry, is a global approach to understanding
regulation of metabolic pathways and metabolic networks of a biological system …

The neuronal ceroid-lipofuscinoses (NCLs), collectively also called Batten disease,
constitute one of the most common groups of inherited neurodegenerative disorders in …