Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …

Pleasure is mediated by well-developed mesocorticolimbic circuitry and serves adaptive
functions. In affective disorders, anhedonia (lack of pleasure) or dysphoria (negative affect) …

Chronic pain syndromes are often refractory to treatment and cause substantial suffering
and disability. Pain severity is often measured through subjective report, while objective …

Chronic pain is a complex neuropsychiatric disorder characterized by sensory, cognitive,
and affective symptoms. Over the past 2 decades, researchers have made significant …

Acute pain is a physiological response that causes an unpleasant sensory and emotional
experience in the presence of actual or potential tissue injury. Anatomically and …

Objective To characterize the functional brain changes involved in δ-9-tetrahydrocannabinol
(THC) modulation of chronic neuropathic pain. Methods Fifteen patients with chronic …

The modulation of brain function via the application of weak direct current was first observed
directly in the early 19th century. In the past 3 decades, transcranial magnetic stimulation …

Deep brain stimulation (DBS) is a neurosurgical intervention popularised in movement
disorders such as Parkinson's disease, and also reported to improve symptoms of epilepsy …

The security of medical devices is critical to good patient care, especially when the devices
are implanted. In light of recent developments in information security, there is reason to be …

Background Deep brain stimulation (DBS) of the anterior cingulate cortex (ACC) is a recent
technique that has shown some promising short-term results in patients with chronic …