While few dispute the existence of the metabolic syndrome as a clustering of factors
indicative of poor metabolic health, its utility above that of its individual components in the …

Stratifying the management of type 2 diabetes (T2D) has to take into account marked
variability in patient phenotype due to heterogeneity in its pathophysiology, different stages …

Physical activity improves the regulation of glucose homeostasis in both type 2 diabetes
(T2D) patients and healthy individuals, but the effect on pancreatic β cell function is …

In pancreatic β cells, mitochondria play a central role in coupling glucose metabolism to
insulin exocytosis, thereby ensuring strict control of glucose-stimulated insulin secretion …

Paraphrasing the Swiss physician and father of toxicology Paracelsus (1493–1541) on
chemical agents used as therapeutics,“the dose makes the poison,” it is now realized that …

A growing body of evidence suggests that hyperglycemia-induced oxidative stress plays an
important role in diabetic complications, especially β-cell dysfunction and failure. Under …

Background Previous studies on the effects of lipotoxicity and oxidative stress on islet beta
cell function mainly focused on patients with diabetes, whereas studies on normal glucose …

Diabetes mellitus (type 1 and type 2) and the complications associated with this condition
are an urgent public health problem, as the incidence of diabetes mellitus is steadily …

Obesity, and the associated disturbed glycerolipid/fatty acid (GL/FA) cycle, contribute to
insulin resistance, islet β-cell failure, and type 2 diabetes. Flux through the GL/FA cycle is …

Recent technical advances have re-invigorated the study of sphingolipid metabolism in
general, and helped to highlight the varied and important roles that sphingolipids play in …