Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery
The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic
model organism for understanding molecular mechanisms of human diseases. Many basic …
model organism for understanding molecular mechanisms of human diseases. Many basic …
[HTML][HTML] Herbal extracts and phytochemicals: plant secondary metabolites and the enhancement of human brain function
DO Kennedy, EL Wightman - Advances in Nutrition, 2011 - Elsevier
Humans consume a wide range of foods, drugs, and dietary supplements that are derived
from plants and which modify the functioning of the central nervous sytem (CNS). The …
from plants and which modify the functioning of the central nervous sytem (CNS). The …
An evidence synthesis of pharmaceuticals and personal care products (PPCPs) in the environment: imbalances among compounds, sewage treatment techniques …
Pharmaceuticals and personal care products (PPCPs) garner increasing attention globally
for both their usefulness as indicators of human waste and their potency as emerging …
for both their usefulness as indicators of human waste and their potency as emerging …
Drosophila as a Model Organism
M Yamaguchi, H Yoshida - Drosophila models for human diseases, 2018 - Springer
Drosophila melanogaster has been widely used in classical and modern genetics for more
than 100 years. The history of the Drosophila model in the study of various aspects of life …
than 100 years. The history of the Drosophila model in the study of various aspects of life …
Identification of a dopamine pathway that regulates sleep and arousal in Drosophila
Sleep is required to maintain physiological functions, including memory, and is regulated by
monoamines across species. Enhancement of dopamine signals by a mutation in the …
monoamines across species. Enhancement of dopamine signals by a mutation in the …
Specific dopaminergic neurons for the formation of labile aversive memory
A paired presentation of an odor and electric shock induces aversive odor memory in
Drosophila melanogaster [1, 2]. Electric shock reinforcement is mediated by dopaminergic …
Drosophila melanogaster [1, 2]. Electric shock reinforcement is mediated by dopaminergic …
The control of sleep and wakefulness by mesolimbic dopamine systems
The mesolimbic dopamine pathway between the ventral tegmental area (VTA) and the
nucleus accumbens (NAc) plays a central role in motivational behaviors. Recent findings …
nucleus accumbens (NAc) plays a central role in motivational behaviors. Recent findings …
Behavioral consequences of dopamine deficiency in the Drosophila central nervous system
T Riemensperger, G Isabel, H Coulom… - Proceedings of the …, 2011 - National Acad Sciences
The neuromodulatory function of dopamine (DA) is an inherent feature of nervous systems of
all animals. To learn more about the function of neural DA in Drosophila, we generated …
all animals. To learn more about the function of neural DA in Drosophila, we generated …
Molecular mechanisms of sleep homeostasis in flies and mammals
Sleep is homeostatically regulated with sleep pressure accumulating with the increasing
duration of prior wakefulness. Yet, a clear understanding of the molecular components of the …
duration of prior wakefulness. Yet, a clear understanding of the molecular components of the …