[HTML][HTML] Tat is a multifunctional viral protein that modulates cellular gene expression and functions
The human immunodeficiency virus type I (HIV-1) has developed several strategies to
condition the host environment to promote viral replication and spread. Viral proteins have …
condition the host environment to promote viral replication and spread. Viral proteins have …
Unraveling the genetics of shared clinical and serological manifestations in patients with systemic inflammatory autoimmune diseases
M Bianchi, SV Kozyrev, A Notarnicola… - Arthritis & …, 2024 - Wiley Online Library
Objective Systemic inflammatory autoimmune diseases (SIADs) such as systemic lupus
erythematosus (SLE), primary Sjögren disease (pSS), and idiopathic inflammatory …
erythematosus (SLE), primary Sjögren disease (pSS), and idiopathic inflammatory …
Cure and long-term remission strategies
L Mori, ST Valente - HIV Reservoirs: Methods and Protocols, 2022 - Springer
The majority of virally suppressed individuals will experience rapid viral rebound upon
antiretroviral therapy (ART) interruption, providing a strong rationale for the development of …
antiretroviral therapy (ART) interruption, providing a strong rationale for the development of …
Mechanism of interferon-stimulated gene induction in HIV-1-infected macrophages
Viruses manipulate the complex interferon and interferon-stimulated gene (ISG) system in
different ways. We have previously shown that HIV inhibits type I and III interferons in its key …
different ways. We have previously shown that HIV inhibits type I and III interferons in its key …
HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells
HIV encodes Tat, a small protein that facilitates viral transcription by binding an RNA
structure (trans-activating RNA [TAR]) formed on nascent viral pre-messenger RNAs …
structure (trans-activating RNA [TAR]) formed on nascent viral pre-messenger RNAs …
SAMHD1 impairs type I interferon induction through the MAVS, IKKε, and IRF7 signaling axis during viral infection
Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) restricts human
immunodeficiency virus type 1 (HIV-1) infection by reducing the intracellular dNTP pool. We …
immunodeficiency virus type 1 (HIV-1) infection by reducing the intracellular dNTP pool. We …
Activation of α7 nicotinic acetylcholine receptor ameliorates HIV-associated neurology and neuropathology
HIV-associated neurocognitive disorders (HAND) in the era of combination antiretroviral
therapy are primarily manifested as impaired behaviours, glial activation/neuroinflammation …
therapy are primarily manifested as impaired behaviours, glial activation/neuroinflammation …
[HTML][HTML] Complement opsonization of HIV-1 results in decreased antiviral and inflammatory responses in immature dendritic cells via CR3
R Ellegård, E Crisci, A Burgener, C Sjöwall… - The Journal of …, 2014 - journals.aai.org
Immature dendritic cells (iDCs) in genital and rectal mucosa may be one of the first cells to
come into contact with HIV-1 during sexual transmission of virus. HIV-1 activates the host …
come into contact with HIV-1 during sexual transmission of virus. HIV-1 activates the host …
[HTML][HTML] Synergistic inflammatory signaling by cGAS may be involved in the development of atherosclerosis
GF Lu, SC Chen, YP Xia, ZM Ye, F Cao, B Hu - Aging (albany NY), 2021 - ncbi.nlm.nih.gov
Inappropriate activation or overactivation of cyclic GMP-AMP synthase (cGAS) by double-
stranded deoxyribonucleic acid (dsDNA) initiates a regulatory signaling cascade triggering a …
stranded deoxyribonucleic acid (dsDNA) initiates a regulatory signaling cascade triggering a …
miRNA regulation of NK cells antiviral response in children with severe and/or recurrent herpes simplex virus infections
M Lenart, E Działo, A Kluczewska… - Frontiers in …, 2021 - frontiersin.org
Severe and/or recurrent infection with Herpes simplex virus (HSV) is observed in a large
group of patients treated in clinical immunology facilities. Atypical and prolonged HSV …
group of patients treated in clinical immunology facilities. Atypical and prolonged HSV …