The microtubule-targeting paclitaxel (PTX) and docetaxel (DTX) are widely used
chemotherapeutic agents. However, the dysregulation of apoptotic processes, microtubule …

Purpose Resistance to endocrine therapy is the primary cause of treatment failure and death
in patients with ER-positive (ER+)/luminal breast cancer. Expression and activation of the …

Background Skin development is a complex process that is influenced by many factors. Pig
skin is used as an ideal material for xenografts because it is more anatomically and …

Introduction Dual-specificity phosphatases (DUSPs) are crucial regulators in many
mammals, managing dephosphorylation and inactivation of mitogen-activated protein …

To better understand the bitterness effect and molecule mechanism of myosin-derived
peptides activating bitter receptors, the interaction between myosin-derived peptides of dry …

Background. The problem of prognostic stratification in acute myeloid leukemia (AML)
patients still has limitations. Methods. The expression profile data and clinical features of …

SPOP is a Cul3 substrate adaptor responsible for degradation of many proteins related to
cell growth and proliferation. Because mutation or misregulation of SPOP drives cancer …

The elucidation of a protein's interaction/association network is important for defining its
biological function. Mass spectrometry–based proteomic approaches have emerged as …

Objective: To investigate the effect of long chain non coding RNA (lncRNA) small nucleolar
RNA host gene 6 (SNHG16) on paclitaxel (PTX) resistance in breast cancer and to …

Senescence is a state of permanent cell cycle arrest which stops proliferation. It is
hallmarked by changes in proteins such as p21, p53, and p16, which are regulated by …