NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility

D Kiyozumi, T Noda, R Yamaguchi, T Tobita… - Science, 2020 - science.org
The lumicrine system is a postulated signaling system in which testis-derived (upstream)
secreted factors enter the male reproductive tract to regulate epididymal (downstream) …

Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice

N Ito, MA Riyadh, SAI Ahmad, S Hattori… - Science translational …, 2021 - science.org
The lateral ventricle (LV) is flanked by the subventricular zone (SVZ), a neural stem cell
(NSC) niche rich in extrinsic growth factors regulating NSC maintenance, proliferation, and …

Regulation of the brain neural niche by soluble molecule akhirin

M Kudo, K Ohta - Journal of Developmental Biology, 2021 - mdpi.com
In the central nervous system (CNS), which comprises the eyes, spinal cord, and brain,
neural cells are produced by the repeated division of neural stem cells (NSCs) during the …

Transcriptome analysis identifies genes involved with the development of umbilical hernias in pigs

MR Souza, AMG Ibelli, IR Savoldi, ME Cantão… - PLoS …, 2020 - journals.plos.org
Umbilical hernia (UH) is one of the most frequent defects affecting pig production, however,
it also affects humans and other mammals. UH is characterized as an abnormal protrusion of …

Common genetic variant in VIT is associated with human brain asymmetry

SH Tadayon, M Vaziri-Pashkam, P Kahali… - Frontiers in human …, 2016 - frontiersin.org
Brain asymmetry varies across individuals. However, genetic factors contributing to this
normal variation are largely unknown. Here we studied variation of cortical surface area …

Shh Protects the Injured Spinal Cord in Mice by Promoting the Proliferation and Inhibiting the Apoptosis of Nerve Cells via the Gli1–TGF–β1/ERK Axis

Y Liu, M Hou, J Wang, X Li, B Zhang… - Cell Biochemistry and …, 2025 - Wiley Online Library
Spinal cord injury (SCI) is a common neurological trauma that cannot be completely cured
with surgical techniques and medications. In this study, we established a mouse SCI model …

A novel nuclear factor Akirin regulating the expression of antimicrobial peptides in Chinese mitten crab Eriocheir sinensis

W Yang, C Liu, Q Xu, C Qu, X Lv, H Li, Z Wu… - Developmental & …, 2019 - Elsevier
Akirin, a recently discovered nuclear factor, participates in regulating various processes,
including cell proliferation and differentiation, embryonic development, and immunity. In the …

Tsukushi is essential for proper maintenance and terminal differentiation of mouse hippocampal neural stem cells

SAI Ahmad, MB Anam, A Istiaq, N Ito… - Development, Growth & …, 2020 - Wiley Online Library
Secreted proteoglycan molecule Tsukushi (TSK) regulates various developmental
processes, such as early body patterning and neural plate formation by interacting with …

Akhirin regulates the proliferation and differentiation of neural stem cells/progenitor cells at neurogenic niches in mouse brain

MB Anam, SAI Ahmad, M Kudo, A Istiaq… - Development …, 2020 - Wiley Online Library
Specialized microenvironment, or neurogenic niche, in embryonic and postnatal mouse
brain plays critical roles during neurogenesis throughout adulthood. The subventricular …

[HTML][HTML] Valproic acid enhances neurosphere formation in cultured rat embryonic cortical cells through TGFβ1 signaling

C Qi, J Zhang, Y Wang, M Lin, J Gao… - Journal of Biomedical …, 2022 - ncbi.nlm.nih.gov
This study aimed to investigate the effect and mechanism of valproic acid (VPA) on the
neurosphere formation in rat embryonic cortical cells. We used free-floating neurosphere …