New perspectives on the potential role of aquaporins (AQPs) in the physiology of inflammation

R Meli, C Pirozzi, A Pelagalli - Frontiers in physiology, 2018 - frontiersin.org
Aquaporins (AQPs) are emerging, in the last few decades, as critical proteins regulating
water fluid homeostasis in cells involved in inflammation. AQPs represent a family of …

Aquaporins in the lung

OH Wittekindt, P Dietl - Pflügers Archiv-European Journal of Physiology, 2019 - Springer
The lung is the interface between air and blood where the exchange of oxygen and carbon
dioxide occurs. The surface liquid that is directly exposed to the gaseous compartment …

Aquaporins in immune cells and inflammation: new targets for drug development

IV da Silva, G Soveral - International journal of molecular sciences, 2021 - mdpi.com
The mammalian immune system senses foreign antigens by mechanisms that involve the
interplay of various kinds of immune cells, culminating in inflammation resolution and tissue …

[HTML][HTML] Hypotheses about sub-optimal hydration in the weeks before coronavirus disease (COVID-19) as a risk factor for dying from COVID-19

JD Stookey, PKR Allu, D Chabas, D Pearce, F Lang - Medical hypotheses, 2020 - Elsevier
To address urgent need for strategies to limit mortality from coronavirus disease 2019
(COVID-19), this review describes experimental, clinical and epidemiological evidence that …

Regeneration of severely damaged lungs using an interventional cross-circulation platform

BA Guenthart, JD O'Neill, J Kim, D Queen… - Nature …, 2019 - nature.com
The number of available donor organs limits lung transplantation, the only lifesaving therapy
for the increasing population of patients with end-stage lung disease. A prevalent etiology of …

[HTML][HTML] A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis

D Wang, B Deng, L Cheng, J Li, J Zhang… - … Pharmaceutica Sinica B, 2023 - Elsevier
Pulmonary fibrosis (PF) is a pathological change caused by repeated injuries and repair
dysfunction of the alveolar epithelium. Our previous study revealed that the residues Asn3 …

The interplay between aquaporin-1 and the hypoxia-inducible factor 1α in a lipopolysaccharide-induced lung injury model in human pulmonary microvascular …

C Keskinidou, NS Lotsios, AG Vassiliou… - International Journal of …, 2022 - mdpi.com
Aquaporin-1 (AQP1), a water channel, and the hypoxia-inducible factor 1α (HIF1A) are
implicated in acute lung injury responses, modulating among others pulmonary vascular …

[HTML][HTML] Aquaporin expression and regulation in clinical and experimental sepsis

NS Lotsios, C Keskinidou, I Dimopoulou… - International Journal of …, 2023 - mdpi.com
Sepsis is an inflammatory disorder caused by the host's dysfunctional response to infection.
Septic patients present diverse clinical characteristics, and in the recent years, it has been …

Mechanistic understanding of lung inflammation: recent advances and emerging techniques

C Keskinidou, AG Vassiliou, I Dimopoulou… - Journal of …, 2022 - Taylor & Francis
Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury characterized by
an acute inflammatory response in the lung parenchyma. Hence, it is considered as the most …

Critical role of aquaporins in cancer: Focus on hematological malignancies

A Allegra, N Cicero, G Mirabile, G Cancemi, A Tonacci… - Cancers, 2022 - mdpi.com
Simple Summary Aquaporins are proteins able to regulate the transfer of water and other
small substances such as ions, glycerol, urea, and hydrogen peroxide across cellular …