Pyrazoles are of considerable interest due to the broad variety of their biological activities.
This overview summarizes structures of pharmacologically interesting pyrazoles, natural …

The natural plant alkaloids caffeine and theophylline were the first adenosine receptor (AR)
antagonists described in the literature. They exhibit micromolar affinities and are non …

The purine alkaloid caffeine is the most widely consumed psychostimulant drug in the world
and has multiple beneficial pharmacological activities, for example, in neurodegenerative …

A midthroughput screening follow-up program targeting the first bromodomain of the human
BRD4 protein, BRD4 (BD1), identified an acetylated-mimic xanthine derivative inhibitor. This …

The purine ring is the most ubiquitous nitrogen-containing heterocycle in nature, 1 since,
besides the numerous purine derivatives found in various marine organisms and plants, it is …

Three novel families of A2B adenosine receptor antagonists were identified in the context of
the structural exploration of the 3, 4-dihydropyrimidin-2 (1 H)-one chemotype. The most …

Caffeine and purine derivatives represent interesting chemical moieties, which show various
biological activities. Caffeine is an alkaloid that belongs to the family of methylxanthine …

Cancer is the uncontrolled growth and development of abnormal cells which is a major
cause of death in both advanced and emerging countries. Although currently chemotherapy …

Novel practical methodology of synthesis of a several types of di-, tri-, and tetraarylpurine
derivatives by a combination of regioselective Suzuki cross-coupling reactions and/or Cu …

Adenosine induces bronchial hyperresponsiveness and inflammation in asthmatics through
activation of A 2B adenosine receptor (A 2B AdoR). Selective antagonists have been shown …