The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

The main protease (M pro) of SARS-CoV-2 is an attractive target in anti-COVID-19 therapy
for its high conservation and major role in the virus life cycle. The covalent M pro inhibitor …

Abstract SARS-CoV-2 main protease (Mpro) is a well-recognized target for COVID-19
therapy. Green tea (−)-epigallocatechin-3-gallate (EGCG) possesses Mpro-inhibitory activity; …

Understanding the origins of past and present viral epidemics is critical in preparing for
future outbreaks. Many viruses, including SARS-CoV-2, have led to significant …

Coronaviruses in general are a zoonotic pathogen with significant cross-species
transmission. They are widely distributed in nature and have recently become a major threat …

Coronaviruses (CoVs) are enveloped positive-sense single-stranded RNA viruses with a
genome that is 27–31 kbases in length. Critical genes include the spike (S), envelope (E) …

Background COVID-19 due to SARS-CoV-2 infection has had an enormous adverse impact
on global public health. As the COVID-19 pandemic evolves, the WHO declared several …

Abstract Global coronavirus disease 2019 (COVID-19) pandemic still threatens human
health and public safety, and the development of effective antiviral agent is urgently needed …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main Protease (Mpro)
is an enzyme that cleaves viral polyproteins translated from the viral genome and is critical …

Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2). 3CLpro is a key enzyme in …